A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
A soma-to-germline transformation in long-lived Caenorhabditis elegans mutants.
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DOI：
10.1038/nature08106
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发表时间：
2009-06-25
期刊：
影响因子：
64.8
通讯作者：
Ruvkun, Gary
中科院分区：
文献类型：
--
作者：
Curran, Sean P.;Wu, Xiaoyun;Riedel, Christian G.;Ruvkun, Gary
不像索马在多细胞生物的生命周期中老化，生殖细胞追踪一个基本上不朽的血统。体细胞中基因组的不稳定性随着年龄的增长而增加，这种体细胞维持能力的下降可能会受到调节，以促进以细胞衰老为代价的生殖资源重新分配。我们在这里报告说，C。具有增加的寿命的线虫突变体表现出通常限于种系的基因表达程序的体细胞到种系的转化。胰岛素样信号传导减少导致肠和外胚层组织中生殖系限制性pie-1和pgl家族基因的体细胞错误表达。胰岛素样信号传导的主要转录效应子β-16/FoxO通过直接结合pie-1启动子来调节pie-1表达。胰岛素样突变体的体细胞组织更像种系，并保护免受遗传毒性应激。诱导寿命增加的胞质伴侣蛋白复合物组分的基因失活也导致PGL-1的体细胞错误表达。这些结果表明，C.具有增加的寿命的秀丽线虫突变体有助于它们增加的健康和存活。
Unlike the soma which ages during the lifespan of multicellular organisms, the germline traces an essentially immortal lineage. Genomic instability in somatic cells increases with age, and this decline in somatic maintenance might be regulated to facilitate resource reallocation toward reproduction at the expense of cellular senescence. We report here that C. elegans mutants with increased longevity exhibit a soma-to-germline transformation of gene expression programs normally limited to the germline. Decreased insulin-like signaling causes the somatic misexpression of germline-limited pie-1 and pgl family of genes in intestinal and ectodermal tissues. DAF-16/FoxO, the major transcriptional effector of insulin-like signaling, regulates pie-1 expression by directly binding to the pie-1 promoter. The somatic tissues of insulin-like mutants are more germline-like and protected from genotoxic stress. Gene inactivation of components of the cytosolic chaperonin complex that induce increased longevity also cause somatic misexpression of PGL-1. These results suggest that the acquisition of germline characteristics by the somatic cells of C. elegans mutants with increased longevity contributes to their increased health and survival.
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