The effect of secondhand smoke exposure on the association between active cigarette smoking and colorectal cancer.
The effect of secondhand smoke exposure on the association between active cigarette smoking and colorectal cancer.
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DOI：
10.1007/s10552-010-9552-3
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发表时间：
2010-08
影响因子：
2.3
通讯作者：
Hyland, Andrew
中科院分区：
文献类型：
--
作者：
Peppone, Luke J.;Reid, Mary E.;Moysich, Kirsten B.;Morrow, Gary R.;Jean-Pierre, Pascal;Mohile, Supriya G.;Darling, Tom V.;Hyland, Andrew
1980年之前发表的研究未能发现吸烟与结直肠癌之间的关联，而随后的研究在考虑了三到四十年的起始期后报告了相关性。本研究的目的是确定考虑二手烟（SHS）暴露对吸烟和结直肠癌之间的关联的影响，并确定SHS和结直肠癌之间的关联。1982年至1998年期间在罗斯韦尔公园癌症研究所治疗的约1,200例结直肠癌病例与2,400例无恶性对照相匹配。通过比较总体样本中每个吸烟变量的比值比（OR）以及那些报告当前无SHS暴露的人的比值比（OR）来确定SHS暴露的影响。在不考虑SHS暴露的情况下，长期重度吸烟男性的结直肠癌几率有小幅显著增加（>45 PY：OR = 1.34; 95% CI 1.04-1.72）。当分析仅限于报告当前无SHS暴露的个体时，OR增加（>45 PY：OR = 2.40; 95% CI 1.36-4.23）。在这项研究中，考虑到SHS暴露导致所有吸烟变量的结直肠癌几率大幅增加。未来的研究应该考虑SHS暴露时，检查吸烟和结直肠癌之间的关联。
Studies published prior to 1980 failed to find an association between smoking and colorectal cancer, while subsequent studies reported an association after accounting for a three to four decade initiation period. The aims of this study were to determine the effect of accounting for secondhand smoke (SHS) exposure on the association between smoking and colorectal cancer and to determine the association between SHS and colorectal cancer. Approximately 1,200 colorectal cancer cases treated at Roswell Park Cancer Institute between 1982 and 1998 were matched to 2,400 malignancy-free controls. The effect of accounting for SHS exposure was determined by comparing the odds ratios (OR) for each smoking variable in the overall sample and then for those who reported no current SHS exposure. A small, significant increase in colorectal cancer odds was noted for heavy, long-term smoking males when not accounting for SHS exposure (>45 PY: OR = 1.34; 95% CI 1.04–1.72). OR increased when the analyses were restricted to individuals reporting no current SHS exposure (>45 PY: OR = 2.40; 95% CI 1.36–4.23). Accounting for SHS exposure resulted in a substantial increase in the odds of colorectal cancer for all smoking variables in this study. Future studies should account for SHS exposure when examining the association between smoking and colorectal cancer.
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影响因子：
4.3
作者：
Corbo, Giuseppe M.;Agabiti, Nera;Forastiere, Francesco
通讯作者：
Forastiere, Francesco
影响因子：
6.4
作者：
Johnson, KC
通讯作者：
Johnson, KC
影响因子：
--
作者：
Haw, Sally J.;Gruer, Laurence
通讯作者：
Gruer, Laurence
影响因子：
2.3
作者：
JACOBSON, JS;NEUGUT, AI;AHSAN, H
通讯作者：
AHSAN, H
DOI：
10.1093/jnci/86.3.192
发表时间：
1994-02-02
期刊：
JOURNAL OF THE NATIONAL CANCER INSTITUTE
影响因子：
--
作者：
GIOVANNUCCI, E;COLDITZ, GA;SPEIZER, FE
通讯作者：
SPEIZER, FE