Natural products as inspiration for the development of bacterial antibiofilm agents.
Natural products as inspiration for the development of bacterial antibiofilm agents.
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DOI：
10.1039/d0np00022a
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发表时间：
2020-11-01
影响因子：
11.9
通讯作者：
Melander C
中科院分区：
文献类型：
--
作者：
Melander RJ;Basak AK;Melander C
Natural products have historically been a rich source of diverse chemical matter with numerous biological activities, and have played an important role in drug discovery in many areas including infectous disease. Synthetic and medicinal chemistry have been, and continue to be, important tools to realize the potential of natural products as therapeutics and as chemical probes. The formation of biofilms by bacteria in an infection setting plays a significant factor in the recalcitrance of many bacterial infections, conferring increased tolerance to many antibiotics and to the host immune reposnse, and as yet there no approved theraputics for combatting biofilm-based bacterial infections. Small molecules that interfere with the ability of bacteria to form and maintain biofilms can overcome antibiotic tolerance conferred by the biofilm phenotype, and have the potential to form combination therapies with conventional antibiotics. Many natural products with anti-biofilm activity have been identified from plants, micobes, and marine life, including: elligic acid glycosides, hamamelitannin, carolacton, skyllamycins, promysalin, phenazines, bromoageliferin, flustramine C, meridianin D, and brominated furanones. Total synthesis and medicinal chemistry programs have facilitated structure confirmation, identification of critical structural motifs, better understanding of mechanistic pathways, and the development of more potent, more accessible, or more pharmacologically favorable derivatives of anti-biofilm natural products.
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影响因子：
15
作者：
Bunders, Cynthia A.;Minvielle, Marine J.;Worthington, Roberta J.;Ortiz, Minoshka;Cavanagh, John;Melander, Christian
通讯作者：
Melander, Christian
影响因子：
4.6
作者：
Brackman G;Breyne K;De Rycke R;Vermote A;Van Nieuwerburgh F;Meyer E;Van Calenbergh S;Coenye T
通讯作者：
Coenye T
影响因子：
2.8
作者：
Bjarnsholt, T;Jensen, PO;Givskov, M
通讯作者：
Givskov, M
影响因子：
3.2
作者：
Bunders C;Cavanagh J;Melander C
通讯作者：
Melander C
影响因子：
4.1
作者：
Brackett, Sara M.;Cox, Karlie E.;Melander, Christian
通讯作者：
Melander, Christian