Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence.
Glucosinolates From Cruciferous Vegetables and Their Potential Role in Chronic Disease: Investigating the Preclinical and Clinical Evidence.
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DOI：
10.3389/fphar.2021.767975
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发表时间：
2021
影响因子：
5.6
通讯作者：
Blekkenhorst LC
中科院分区：
文献类型：
--
作者：
Connolly EL;Sim M;Travica N;Marx W;Beasy G;Lynch GS;Bondonno CP;Lewis JR;Hodgson JM;Blekkenhorst LC
越来越多的证据表明，富含水果和蔬菜的饮食有很大的潜力，可以延迟并经常预防慢性疾病的发作，包括心脏代谢、神经和肌肉骨骼疾病以及某些癌症。一种可能的保护成分，硫代葡萄糖苷，这是植物化学物质发现几乎只在十字花科蔬菜，已确定从临床前和临床研究。目前的研究表明，芥子油苷（和异硫氰酸酯）通过几种机制发挥作用，最终表现出抗炎，抗氧化和化学保护作用。本文综述了目前的知识，围绕十字花科蔬菜及其硫代葡萄糖苷有关的特定的健康状况。虽然有证据表明，高硫代葡萄糖酸盐饮食的消费与慢性疾病的发病率降低，未来的大规模安慰剂对照人体试验，包括标准化的硫代葡萄糖酸盐补充剂是必要的。
An increasing body of evidence highlights the strong potential for a diet rich in fruit and vegetables to delay, and often prevent, the onset of chronic diseases, including cardiometabolic, neurological, and musculoskeletal conditions, and certain cancers. A possible protective component, glucosinolates, which are phytochemicals found almost exclusively in cruciferous vegetables, have been identified from preclinical and clinical studies. Current research suggests that glucosinolates (and isothiocyanates) act via several mechanisms, ultimately exhibiting anti-inflammatory, antioxidant, and chemo-protective effects. This review summarizes the current knowledge surrounding cruciferous vegetables and their glucosinolates in relation to the specified health conditions. Although there is evidence that consumption of a high glucosinolate diet is linked with reduced incidence of chronic diseases, future large-scale placebo-controlled human trials including standardized glucosinolate supplements are needed.
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Sulforaphane通过NRF2信号传导可防止与年龄相关的心脏和肌肉功能障碍。
影响因子：
7.8
作者：
Bose C;Alves I;Singh P;Palade PT;Carvalho E;Børsheim E;Jun SR;Cheema A;Boerma M;Awasthi S;Singh SP
通讯作者：
Singh SP
影响因子：
3.7
作者：
Christiansen B;Bellostas Muguerza N;Petersen AM;Kveiborg B;Madsen CR;Thomas H;Ihlemann N;Sørensen JC;Køber L;Sørensen H;Torp-Pedersen C;Domínguez H
通讯作者：
Domínguez H
影响因子：
17.1
作者：
Axelsson, Annika S.;Tubbs, Emily;Rosengren, Anders H.
通讯作者：
Rosengren, Anders H.
影响因子：
5.4
作者：
Blekkenhorst, Lauren C.;Bondonno, Catherine P.;Hodgson, Jonathan M.
通讯作者：
Hodgson, Jonathan M.
影响因子：
8.1
作者：
Casajus, Victoria;Demkura, Patricia;Martinez, Gustavo
通讯作者：
Martinez, Gustavo