Eliciting B cell immunity against infectious diseases using nanovaccines.
Eliciting B cell immunity against infectious diseases using nanovaccines.
复制标题
使用纳米疫苗引发针对传染病的 B 细胞免疫。
DOI：
10.1038/s41565-020-00790-3
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发表时间：
2021-01
影响因子：
38.3
通讯作者：
Singh A
中科院分区：
文献类型：
--
作者：
Singh A
传染病，包括使世界陷入停滞的2019冠状病毒病（COVID - 19）大流行，正以前所未有的速度出现，对公共卫生和全球经济产生重大影响。对于许多危及生命的全球性传染病，如人类免疫缺陷病毒（HIV）感染、疟疾和流感，仍然缺乏有效的疫苗。开发新疫苗存在诸多障碍，包括对这些全球性感染的免疫保护相关因素了解有限。为了诱导针对棘手病原体的可重复的、强烈的免疫反应，复杂的纳米疫苗技术正在研究中。与传统疫苗相比，纳米疫苗能更好地进入淋巴结，对抗原进行优化包装和呈递，并诱导持久的免疫反应。本综述阐述了针对传染病的新兴纳米疫苗的全球趋势，描述了与其开发相关的生物学、实验和后勤问题，以及如何利用免疫工程来克服这些挑战。
Infectious diseases, including the coronavirus disease 2019 (COVID-19) pandemic that has brought the world to a standstill, are emerging at an unprecedented rate with a substantial impact on public health and global economies. For many life-threatening global infectious diseases, such as human immunodeficiency virus (HIV) infection, malaria and influenza, effective vaccinations are still lacking. There are numerous roadblocks to developing new vaccines, including a limited understanding of immune correlates of protection to these global infections. To induce a reproducible, strong immune response against difficult pathogens, sophisticated nanovaccine technologies are under investigation. In contrast to conventional vaccines, nanovaccines provide improved access to lymph nodes, optimal packing and presentation of antigens, and induction of a persistent immune response. This Review provides a perspective on the global trends in emerging nanoscale vaccines for infectious diseases and describes the biological, experimental and logistical problems associated with their development, and how immunoengineering can be leveraged to overcome these challenges.
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影响因子：
46.9
作者：
通讯作者：
--
影响因子：
8.8
作者：
Chambers BS;Parkhouse K;Ross TM;Alby K;Hensley SE
通讯作者：
Hensley SE
影响因子：
30.5
作者：
Akkaya M;Traba J;Roesler AS;Miozzo P;Akkaya B;Theall BP;Sohn H;Pena M;Smelkinson M;Kabat J;Dahlstrom E;Dorward DW;Skinner J;Sack MN;Pierce SK
通讯作者：
Pierce SK
DOI：
10.1126/science.1234150
发表时间：
2013-05-10
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Jardine J;Julien JP;Menis S;Ota T;Kalyuzhniy O;McGuire A;Sok D;Huang PS;MacPherson S;Jones M;Nieusma T;Mathison J;Baker D;Ward AB;Burton DR;Stamatatos L;Nemazee D;Wilson IA;Schief WR
通讯作者：
Schief WR
影响因子：
9.2
作者：
Kamp, Heather D.;Swanson, Kurt A.;Nabel, Gary J.
通讯作者：
Nabel, Gary J.