A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.
A comparison of selected quantitative trait loci associated with alcohol use phenotypes in humans and mouse models.
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DOI：
10.1111/j.1369-1600.2009.00195.x
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发表时间：
2010-04
影响因子：
3.4
通讯作者：
Crabbe JC
中科院分区：
文献类型：
--
作者：
Ehlers CL;Walter NA;Dick DM;Buck KJ;Crabbe JC
人类和小鼠基因组区域与酒精和其他物质依赖表型的遗传联系的证据现已报道，各研究之间具有一定的一致性。然而，问题仍然是，在小鼠中观察到的与酒精相关的行为背后的基因是否与在人类酗酒者中观察到的行为背后的基因相同。当前一组分析的目的是确定人类和小鼠中一小部分与酒精相关的表型，通过同线性作图比较物种之间的数量性状基因座 (QTL) 数据。这些分析发现，小鼠 1 号染色体远端上与饮酒和急性和慢性酒精戒断有关的 QTL 与人类 1q 染色体上的一个区域是同线性的，许多研究已经在该区域鉴定了与酒精相关表型的 QTL。此外，在两项人类研究中发现，人类 15 号染色体上的一个与酒精依赖严重程度/戒断相关的 QTL 与小鼠 9 号染色体上的一个区域在很大程度上是同线性的，在该区域，两个研究小组都发现了与酒精偏好有关的 QTL。在这两种情况下，虽然 QTL 被发现是同线性的，但人类和小鼠之间的确切表型不一定重叠。这些研究证明了该技术如何有助于在多个物种中寻找与酒精相关表型相关的基因。然而，这些发现还表明，为了确定相似的基因是否影响两个物种之间一系列与酒精相关的行为，尝试匹配人类和小鼠的精确表型可能不是必要的，甚至不是最佳的。
Evidence for genetic linkage to alcohol and other substance dependence phenotypes in areas of the human and mouse genome have now been reported with some consistency across studies. However, the question remains as to whether the genes that underlie the alcohol-related behaviors seen in mice are the same as those that underlie the behaviors observed in human alcoholics. The aims of the current set of analyses were to identify a small set of alcohol-related phenotypes in humans and in mouse by which to compare quantitative trait locus (QTL) data between the species using syntenic mapping. These analyses identified that QTLs for alcohol consumption and acute and chronic alcohol withdrawal on distal mouse chromosome 1 are syntenic to a region on human chromosome 1q where a number of studies have identified QTLs for alcohol-related phenotypes. Additionally, a QTL on human chromosome 15 for alcohol dependence severity/withdrawal identified in two human studies was found to be largely syntenic with a region on mouse chromosome 9 where two groups have found QTLs for alcohol preference. In both of these cases while the QTLs were found to be syntenic the exact phenotypes between humans and mice did not necessarily overlap. These studies demonstrate how this technique might be useful in the search for genes underlying alcohol-related phenotypes in multiple species. However, these findings also suggest that trying to match exact phenotypes in humans and mice may not be necessary or even optimal for determining whether similar genes influence a range of alcohol-related behaviors between the two species.
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影响因子：
15.9
作者：
Crowder, CM
通讯作者：
Crowder, CM
DOI：
10.15288/jsa.1979.40.89
发表时间：
1979-01-01
期刊：
JOURNAL OF STUDIES ON ALCOHOL
影响因子：
--
作者：
COTTON, NS
通讯作者：
COTTON, NS
DOI：
10.1002/ajmg.b.30091
发表时间：
2004-08-15
影响因子：
2.8
作者：
Covault, J;Gelernter, J;Kranzler, HR
通讯作者：
Kranzler, HR
影响因子：
2.5
作者：
Bennett, B.;Carosone-Link, P.;Johnson, T. E.
通讯作者：
Johnson, T. E.
DOI：
10.1124/jpet.106.103572
发表时间：
2006-10-01
影响因子：
3.5
作者：
Bennett, Beth;Carosone-Link, Phyllis;Johnson, Thomas E.
通讯作者：
Johnson, Thomas E.