Low risk of necrotising enterocolitis in enterally fed neonates with critical heart disease: an observational study.
Low risk of necrotising enterocolitis in enterally fed neonates with critical heart disease: an observational study.
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DOI：
10.1136/archdischild-2019-318537
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Elfvin A
中科院分区：
文献类型：
--
作者：
Nordenström K;Lannering K;Mellander M;Elfvin A
我们旨在调查患有危重先天性心脏病 (CCHD) 的婴儿坏死性小肠结肠炎 (NEC) 的发生率，假设术前肠内喂养不会增加 NEC 的风险。当 NEC 影响足月婴儿时，经常会发现潜在的危险因素，如窒息、败血症或 CCHD。由于担心患有 CCHD 的婴儿出现 NEC，许多国家都非常谨慎地推迟术前肠内喂养，但在瑞典，这是常规提供的。对 2010 年至 2017 年间入住哥德堡西尔维娅王后儿童医院的所有出生患有 CCHD 的婴儿进行的观察性研究。使用国际疾病分类第 10 版 NEC 诊断代码来识别该组 NEC 病例。确定了被描述为“完全喂养”或在心脏手术前每天喂养至少 45 mL/kg 的婴儿。 CCHD 婴儿的 NEC 与术前肠内喂养相关。研究期间收治了 458 名患有 CCHD 的婴儿。 408/458 是足月出生的，361/458 在手术前需要前列腺素 E1。总共有 444/458 名婴儿 (97%) 在心脏手术前每天完全喂养或喂养至少 45 mL/kg。 458 名婴儿中有 4 名患有 NEC（0.9%）。所有四人都有其他 NEC 风险因素。这项研究表明，心脏手术前肠内喂养的足月婴儿发生 NEC 的风险较低。我们推测 CCHD 新生儿的术前肠内喂养不会增加 NEC 发生的风险。
We aimed to investigate the frequency of necrotising enterocolitis (NEC) in infants with critical congenital heart disease (CCHD) hypothesising that preoperative enteral feeding does not increase the risk of NEC. When NEC affects term infants, underlying risk factors such as asphyxia, sepsis or CCHD are often found. Due to fear of NEC development in infants with CCHD great caution is practised in many countries to defer preoperative enteral feeding, but in Sweden this is routinely provided. An observational study of all infants born with CCHD who were admitted to Queen Silvia Children’s Hospital in Gothenburg between 2010 and 2017. The International Classification of Diseases 10th Revision diagnosis code of NEC was used to identify NEC cases in this group. Infants described as ‘fully fed’ or who were fed at least 45 mL/kg/day before cardiac surgery were identified. NEC in infants with CCHD in relation to preoperative enteral feeding. There were 458 infants with CCHD admitted during the study period. 408/458 were born at term and 361/458 required prostaglandin E1 before surgery. In total, 444/458 infants (97%) were fully fed or fed at least 45 mL/kg daily before cardiac surgery. Four of 458 infants developed NEC (0.9%). All four had other risk factors for NEC. This study showed a low risk of NEC in term infants fed enterally before cardiac surgery. We speculate that preoperative enteral feeding of neonates with CCHD does not increase the risk of NEC development.
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影响因子：
8
作者：
McElhinney, DB;Hedrick, HL;Wernovsky, G
通讯作者：
Wernovsky, G
影响因子：
2.1
作者：
Garcia, Heladia;Cervantes-Luna, Beatriz;Miranda-Novales, Guadalupe
通讯作者：
Miranda-Novales, Guadalupe
影响因子：
3
作者：
de la Cruz, Diomel;Bazacliu, Catalina
通讯作者：
Bazacliu, Catalina
DOI：
10.1177/2150135116668833
发表时间：
2017-01
影响因子：
0.9
作者：
Scahill CJ;Graham EM;Atz AM;Bradley SM;Kavarana MN;Zyblewski SC
通讯作者：
Zyblewski SC
影响因子：
2.1
作者：
Jakaitis BM;Denning PW
通讯作者：
Denning PW