Resting-state brain connectivity after surgical and behavioral weight loss.
Resting-state brain connectivity after surgical and behavioral weight loss.
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DOI：
10.1002/oby.21119
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发表时间：
2015-07
期刊：
影响因子：
6.9
通讯作者：
Bruce, Jared M.
中科院分区：
文献类型：
--
作者：
Lepping, Rebecca J.;Bruce, Amanda S.;Francisco, Alex;Yeh, Hung-Wen;Martin, Laura E.;Powell, Joshua N.;Hancock, Laura;Patrician, Trisha M.;Breslin, Florence J.;Selim, Niazy;Donnelly, Joseph E.;Brooks, William M.;Savage, Cary R.;Simmons, W. Kyle;Bruce, Jared M.
我们之前报道过与行为和手术减肥干预相关的食物提示神经反应的变化。静息功能连接代表可能有助于减肥成功的强直神经活动。在这里，我们探讨干预类型是否与减肥后功能连接的差异相关。在可调节胃束带手术之前招募了 15 名肥胖参与者。从单独的行为饮食干预中选出了 13 名人口统计匹配的肥胖参与者。手术/行为干预后三个月收集静息态功能磁共振成像。方差分析用于检查减肥后两组之间与种子区域的连接差异，之前确定这些区域在减肥后显示出不同的线索反应性。体重减轻后，行为节食者在餐前至餐后表现出左楔前叶/顶上小叶（SPL）和双侧岛叶之间的连接性增加，而肥胖患者在餐前至餐后这些区域之间的连接性降低（p校正<.05）。行为节食者表现出餐前至餐后与自我参照信息处理相关的区域（楔前叶/SPL）和与内感受相关的区域（岛叶）之间的连通性增加，而肥胖患者则表现出这些区域之间的连通性降低。这可能反映了外科手术后对饥饿信号的更多关注，以及行为饮食干预后对饱腹感信号的更多关注。
We previously reported changes in food-cue neural reactivity associated with behavioral and surgical weight loss interventions. Resting functional connectivity represents tonic neural activity that may contribute to weight loss success. Here we explore whether intervention type is associated with differences in functional connectivity after weight loss. Fifteen obese participants were recruited prior to adjustable gastric banding surgery. Thirteen demographically matched obese participants were selected from a separate behavioral diet intervention. Resting state fMRI was collected three months after surgery/behavioral intervention. ANOVA was used to examine post-weight loss differences between the two groups in connectivity to seed regions previously identified as showing differential cue-reactivity after weight loss. Following weight loss, behavioral dieters exhibited increased connectivity between left precuneus/superior parietal lobule (SPL) and bilateral insula pre- to post-meal and bariatric patients exhibited decreased connectivity between these regions pre- to post-meal (pcorrected<.05). Behavioral dieters showed increased connectivity pre- to post-meal between a region associated with processing of self-referent information (precuneus/SPL) and a region associated with interoception (insula) whereas bariatric patients showed decreased connectivity between these regions. This may reflect increased attention to hunger signals following surgical procedures, and increased attention to satiety signals following behavioral diet interventions.
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