Systolic hypertension: an increasing clinical challenge in Asia.

Systolic hypertension: an increasing clinical challenge in Asia.
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收缩压:亚洲的临床挑战日益增加。

DOI:
10.1038/hr.2014.169
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发表时间:
2015-04
影响因子:
5.4
通讯作者:
Wang, Ji-Guang
Wang, Ji-Guang
中科院分区:
医学2区
文献类型:
--
作者:
Park, Jeong Bae;Kario, Kazuomi;Wang, Ji-Guang

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收缩期高血压是50-60岁以上患者的主要高血压形式,随着亚洲人口的老龄化,这是一个日益严重的健康问题。收缩压升高主要是由年龄相关的血管变化引起的动脉硬化引起的。收缩压升高会增加心血管疾病、死亡率和肾功能下降的风险,亚洲受试者的收缩压水平低于西方受试者时,这种风险可能会增加。因此,有效降低收缩压在亚洲人中尤为重要,尽管有许多抗高血压药物,但血压控制仍然不足。血压控制不佳的原因包括卫生保健专业人员和患者对高血压的认识不足,治疗不足以及抗高血压药物的耐受性问题。目前的抗高血压治疗也缺乏对收缩期高血压的基础血管病理学的影响,因此需要解决动脉硬化的病理生理学的新型药物来优化收缩期高血压及其心血管并发症的管理。
Systolic hypertension, the predominant form of hypertension in patients aged over 50–60 years, is a growing health issue as the Asian population ages. Elevated systolic blood pressure is mainly caused by arterial stiffening, resulting from age-related vascular changes. Elevated systolic pressure increases the risk of cardiovascular disease, mortality and renal function decline, and this risk may increase at lower systolic pressure levels in Asian than Western subjects. Hence, effective systolic pressure lowering is particularly important in Asians yet blood pressure control remains inadequate despite the availability of numerous antihypertensive medications. Reasons for poor blood pressure control include low awareness of hypertension among health-care professionals and patients, under-treatment, and tolerability problems with antihypertensive drugs. Current antihypertensive treatments also lack effects on the underlying vascular pathology of systolic hypertension, so novel drugs that address the pathophysiology of arterial stiffening are needed for optimal management of systolic hypertension and its cardiovascular complications.
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