Untapped Potentials of Endophytic Fungi: A Review of Novel Bioactive Compounds with Biological Applications.
Untapped Potentials of Endophytic Fungi: A Review of Novel Bioactive Compounds with Biological Applications.
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内生真菌的未开发潜力：具有生物学应用的新型生物活性化合物综述。
DOI：
10.3390/microorganisms8121934
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发表时间：
2020-12-06
期刊：
影响因子：
4.5
通讯作者：
Ateba CN
中科院分区：
文献类型：
--
作者：
Manganyi MC;Ateba CN
在过去的一个世纪里，内生真菌由于能够产生具有不同生物学特性的新型生物活性化合物而受到极大的关注，因此被用于医药和农业应用。内生真菌存在于植物组织内，没有表现出任何疾病症状，因此支持寄主植物的生理和生态属性。由内生真菌产生的突破性先导化合物，如紫杉醇和青霉素，为探索具有商业用途的新型生物活性化合物铺平了道路。尽管如此，在这一有价值和独特的利基领域进行的研究有限。这些生物活性化合物属于不同的结构基团，包括生物碱、多肽、甾体、萜类、酚、醌、酚和黄酮类。综述了内生真菌在产生具有抗菌、抗病毒、抗真菌、抗原生动物、抗寄生虫、抗氧化、免疫抑制和抗癌等多种生物活性物质方面的重要意义。考虑到本出版物的门户网站，特别强调了内生菌产生的代谢物对人类病原体的抗微生物和抗病毒活性。它还强调了利用这些化合物作为严重威胁生命的传染病的潜在治疗剂的重要性。一些研究结果表明，这些生物活性化合物可能大大有助于对抗具有抗药性的人类和植物病原体，因此需要加强寻找新的、更有效和更具成本效益的抗微生物药物，这一事实支持了这一点。
Over the last century, endophytic fungi have gained tremendous attention due to their ability to produce novel bioactive compounds exhibiting varied biological properties and are, therefore, utilized for medicinal, pharmaceutical, and agricultural applications. Endophytic fungi reside within the plant tissues without showing any disease symptoms, thus supporting the physiological and ecological attributes of the host plant. Ground breaking lead compounds, such as paclitaxel and penicillin, produced by endophytic fungi have paved the way for exploring novel bioactive compounds for commercial usage. Despite this, limited research has been conducted in this valuable and unique niche area. These bioactive compounds belong to various structural groups, including alkaloids, peptides, steroids, terpenoids, phenols, quinones, phenols, and flavonoids. The current review focuses on the significance of endophytic fungi in producing novel bioactive compounds possessing a variety of biological properties that include antibacterial, antiviral, antifungal, antiprotozoal, antiparasitic, antioxidant, immunosuppressant, and anticancer functions. Taking into consideration the portal of this publication, special emphasis is placed on the antimicrobial and antiviral activities of metabolites produced by endophytes against human pathogens. It also highlights the importance of utilization of these compounds as potential treatment agents for serious life-threatening infectious diseases. This is supported by the fact that several findings have indicated that these bioactive compounds may significantly contribute towards the fight against resistant human and plant pathogens, thus motivating the need enhance the search for new, more efficacious and cost-effective antimicrobial drugs.
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