Neural processing underlying tactile microspatial discrimination in the blind: a functional magnetic resonance imaging study.
Neural processing underlying tactile microspatial discrimination in the blind: a functional magnetic resonance imaging study.
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DOI：
10.1167/8.10.13
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发表时间：
2008-12-17
影响因子：
1.8
通讯作者：
Sathian K
中科院分区：
文献类型：
--
作者：
Stilla R;Hanna R;Hu X;Mariola E;Deshpande G;Sathian K
虽然失明改变了非视觉任务的新皮层处理，以前的研究不允许纯知觉任务的明确结论。我们使用功能性磁共振成像（fMRI）来研究盲人触觉微空间辨别的神经加工。触觉微空间任务期间的活动进行了对比，在触觉时间歧视任务。空间选择性网络包括额顶叶和视觉皮层区域。左侧初级躯体感觉皮层和视觉皮层病灶的激活幅度可预测视力阈值。使用多变量格兰杰因果关系分析研究有效连接。双侧原发性躯体感觉皮质病灶和左侧颞下病灶是重要的连接来源。视觉皮层区域主要相互作用，并与体感皮层区域。在一组分布的皮层区域表现出更大的空间选择性，在早期盲晚盲的个人相比，完全失明的年龄预测的活动在一个子集的额顶叶区域，并从右侧枕叶复合体右枕极皮层的路径的重量。因此，触觉微空间辨别过程中神经处理的许多方面在盲人和有视力的人之间存在差异，其中一些关键差异反映了盲人的视觉皮层参与。
Although blindness alters neocortical processing of non-visual tasks, previous studies do not allow clear conclusions about purely perceptual tasks. We used functional magnetic resonance imaging (fMRI) to examine the neural processing underlying tactile microspatial discrimination in the blind. Activity during the tactile microspatial task was contrasted against that during a tactile temporal discrimination task. The spatially-selective network included frontoparietal and visual cortical regions. Activation magnitudes in left primary somatosensory cortex and in visual cortical foci predicted acuity thresholds. Effective connectivity was investigated using multivariate Granger causality analyses. Bilateral primary somatosensory cortical foci and a left inferior temporal focus were important sources of connections. Visual cortical regions interacted mainly with one another and with somatosensory cortical regions. Among a set of distributed cortical regions exhibiting greater spatial selectivity in early blind compared to late blind individuals, the age of complete blindness was predicted by activity in a subset of frontoparietal regions, and by the weight of a path from the right lateral occipital complex to right occipitopolar cortex. Thus, many aspects of neural processing during tactile microspatial discrimination differ between the blind and sighted, with some of the key differences reflecting visual cortical engagement in the blind.
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