What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review.
What are the neural correlates of meta-cognition and anosognosia in Alzheimer's disease? A systematic review.
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DOI：
10.1016/j.neurobiolaging.2020.06.011
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发表时间：
2020-10
影响因子：
4.2
通讯作者：
Huntley J
中科院分区：
文献类型：
--
作者：
Hallam B;Chan J;Gonzalez Costafreda S;Bhome R;Huntley J
阿尔茨海默病（AD）患者对自身认知过程（元认知）或自身疾病或缺陷（病感失认症）的意识可能受损。阿尔茨海默病病感失认症的神经相关性仍不确定。了解病感失认症是很重要的，因为它对护理人员负担和增加制度化的影响。对结构和功能神经影像学研究进行了系统回顾，以确定与AD病感失认相关的特定大脑区域。系统评价纳入了32项研究。阿尔茨海默病患者脑灰质密度、脑血流量和8个关键区域代谢降低与病感失认评分增加显著相关。最常见的相关区域是额下回、前扣带皮层和内侧颞叶。其他关键区域包括额上回、额内侧回、眶额皮质、后扣带皮质和脑岛。识别与病感失认相关的大脑区域可以帮助理解和识别阿尔茨海默病患者的病感失认，并有可能促进护理的改善。系统评价中包括32项研究。8个关键的大脑区域与阿尔茨海默病的病感失认症有关。减少的灰质密度和脑血流量与病感失认症有关。需要更多同质性研究才能进行荟萃分析。
Awareness of one's own cognitive processes (metacognition) or of one's own illness or deficits (anosognosia) can be impaired in people with Alzheimer's disease (AD). The neural correlates of anosognosia within AD remain inconclusive. Understanding anosognosia is of importance because of its impact on carer burden and increased institutionalization. A systematic review of structural and functional neuroimaging studies was conducted to identify specific brain regions associated with anosognosia within AD. Thirty-two studies were included in the systematic review. Reduced gray matter density, cerebral blood flow, and hypometabolism in 8 key regions were significantly associated with increased anosognosia scores in people with AD. The most frequently associated regions were the inferior frontal gyrus, anterior cingulate cortex, and medial temporal lobe. Other key regions include the superior frontal gyrus, medial frontal gyrus, orbitofrontal cortex, posterior cingulate cortex, and the insula. Identifying brain regions associated with anosognosia can aid understanding and identification of anosognosia in people with AD and potentially facilitate improvements in care. Thirty-two studies included within the systematic review. Eight key brain regions were linked with anosognosia within Alzheimer's disease. Reduced gray matter density and cerebral blood flow linked with anosognosia. More homogenous studies needed to be able to conduct meta-analysis.
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影响因子：
3.6
作者：
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通讯作者：
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影响因子：
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作者：
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