Effect of covid-19 vaccination on long covid: systematic review.
Effect of covid-19 vaccination on long covid: systematic review.
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DOI：
10.1136/bmjmed-2022-000385
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Glasziou, Paul
中科院分区：
文献类型：
--
作者：
Byambasuren, Oyungerel;Stehlik, Paulina;Clark, Justin;Alcorn, Kylie;Glasziou, Paul
关键词：
目的：探讨急性感染SARS-CoV-2前后或确诊为长时间感染后接种新冠肺炎对长时间感染的发生率和症状的影响。系统回顾。PubMed、Embase和Cochrane新冠肺炎试用版，以及欧洲PubMed Central(欧洲PMC)的预印本，从2020年1月1日至2022年8月3日。试验、队列研究和病例对照研究，报告了在感染SARS-CoV-2病毒前后或在被诊断为长Covid之后接种疫苗的长衣壳和长衣壳症状的患者。使用Robins-I工具评估偏倚的风险。共筛选了1645篇文章，但没有发现随机对照试验。来自5个国家(美国、英国、法国、意大利和荷兰)的16项观察性研究被确定，报告了614名 392名患者。最常见的症状是疲劳、咳嗽、嗅觉丧失、呼吸短促、味觉减退、头痛、肌肉酸痛、难以入睡、注意力不集中、焦虑或焦虑，以及记忆力丧失或困惑。12项研究报告了在感染SARS-CoV-2病毒前接种疫苗的数据，其中10项研究显示长冠状病毒的发病率显著降低：接种一剂疫苗后出现长冠状病毒的优势比为0.22至1.03；接种两剂疫苗的优势比为0.25-1；接种三剂疫苗的优势比为0.16；任何一剂疫苗的优势比为0.48-1.01。有五项研究报告了感染后接种疫苗的情况，优势比为0.38-0.91。研究之间的高度异质性排除了任何有意义的荟萃分析。这些研究未能调整潜在的混杂因素，如其他保护性行为和数据缺失，从而增加了偏见的风险，并将证据的确定性降低到低水平。目前的研究表明，新冠肺炎疫苗可能对长Covie具有保护和治疗作用。然而，需要更有力的比较观察性研究和试验，才能清楚地确定疫苗在预防和治疗长期Covid方面的有效性。开放科学框架https://osf.io/e8jdy.
To determine the effect of covid-19 vaccination, given before and after acute infection with the SARS-CoV-2 virus, or after a diagnosis of long covid, on the rates and symptoms of long covid. Systematic review. PubMed, Embase, and Cochrane covid-19 trials, and Europe PubMed Central (Europe PMC) for preprints, from 1 January 2020 to 3 August 2022. Trials, cohort studies, and case-control studies reporting on patients with long covid and symptoms of long covid, with vaccination before and after infection with the SARS-CoV-2 virus, or after a diagnosis of long covid. Risk of bias was assessed with the ROBINS-I tool. 1645 articles were screened but no randomised controlled trials were found. 16 observational studies from five countries (USA, UK, France, Italy, and the Netherlands) were identified that reported on 614 392 patients. The most common symptoms of long covid that were studied were fatigue, cough, loss of sense of smell, shortness of breath, loss of taste, headache, muscle ache, difficulty sleeping, difficulty concentrating, worry or anxiety, and memory loss or confusion. 12 studies reported data on vaccination before infection with the SARS-CoV-2 virus, and 10 showed a significant reduction in the incidence of long covid: the odds ratio of developing long covid with one dose of vaccine ranged from 0.22 to 1.03; with two doses, odds ratios were 0.25-1; with three doses, 0.16; and with any dose, 0.48-1.01. Five studies reported on vaccination after infection, with odds ratios of 0.38-0.91. The high heterogeneity between studies precluded any meaningful meta-analysis. The studies failed to adjust for potential confounders, such as other protective behaviours and missing data, thus increasing the risk of bias and decreasing the certainty of evidence to low. Current studies suggest that covid-19 vaccines might have protective and therapeutic effects on long covid. More robust comparative observational studies and trials are needed, however, to clearly determine the effectiveness of vaccines in preventing and treating long covid. Open Science Framework https://osf.io/e8jdy.
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DOI：
10.1016/j.cmi.2022.03.016
发表时间：
2022-08
期刊：
Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
影响因子：
--
作者：
Peghin M;De Martino M;Palese A;Gerussi V;Bontempo G;Graziano E;Visintini E;D'Elia D;Dellai F;Marrella F;Fabris M;Curcio F;Sartor A;Isola M;Tascini C
通讯作者：
Tascini C
影响因子：
3.2
作者：
Mumtaz, Aqsa;Sheikh, Abdul Ahad Ehsan;Khan, Amin Moazzam;Khalid, Subaina Naeem;Khan, Jehanzaeb;Nasrullah, Adeel;Sagheer, Shazib;Sheikh, Abu Baker
通讯作者：
Sheikh, Abu Baker
COVID-19 的 50 多种长期影响：系统回顾和荟萃分析。
影响因子：
4.6
作者：
Lopez-Leon S;Wegman-Ostrosky T;Perelman C;Sepulveda R;Rebolledo PA;Cuapio A;Villapol S
通讯作者：
Villapol S
影响因子：
9.2
作者：
通讯作者：
--
DOI：
10.1016/s1473-3099(21)00460-6
发表时间：
2022-01
期刊：
The Lancet. Infectious diseases
影响因子：
--
作者：
Antonelli M;Penfold RS;Merino J;Sudre CH;Molteni E;Berry S;Canas LS;Graham MS;Klaser K;Modat M;Murray B;Kerfoot E;Chen L;Deng J;Österdahl MF;Cheetham NJ;Drew DA;Nguyen LH;Pujol JC;Hu C;Selvachandran S;Polidori L;May A;Wolf J;Chan AT;Hammers A;Duncan EL;Spector TD;Ourselin S;Steves CJ
通讯作者：
Steves CJ