Effects of exercise modalities on arterial stiffness and wave reflection: a systematic review and meta-analysis of randomized controlled trials.
Effects of exercise modalities on arterial stiffness and wave reflection: a systematic review and meta-analysis of randomized controlled trials.
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DOI：
10.1371/journal.pone.0110034
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Mathers JC
中科院分区：
文献类型：
--
作者：
Ashor AW;Lara J;Siervo M;Celis-Morales C;Mathers JC
体力活动与较低的心血管疾病死亡率和全因死亡率相关。然而，不同运动方式对动脉僵硬度的影响目前尚不清楚。我们的目的是研究运动方式（有氧运动、抗阻运动或两者结合）对脉搏波速度（PWV）和增强指数（AIx）的影响，并确定这些影响是否因参与者或运动特征而异。
我们检索了从建库至2014年4月的Medline、Embase和Cochrane图书馆数据库，查找持续时间≥4周的随机对照试验，这些试验研究运动方式对≥18岁成年人的PWV和AIx的影响。
本分析纳入了42项研究（1627名参与者）。有氧运动显著改善了PWV（加权均数差：−0.63 m/s，95%置信区间：−0.90，−0.35）和AIx（加权均数差：−2.63%，95%置信区间：−5.25至−0.02）。有氧运动训练显示肱 - 踝PWV（加权均数差：−1.01 m/s，95%置信区间：−1.57，−0.44）的降低幅度显著大于颈 - 股PWV（加权均数差：−0.39 m/s，95%置信区间：−0.52，−0.27）。较高的有氧运动强度与AIx更大幅度的降低相关（β：−1.55%，置信区间−3.09，0.0001）。此外，在动脉更僵硬（PWV≥8 m/s）的参与者中，有氧运动在降低PWV方面有更显著的效果（加权均数差：−1.0 m/s，95%置信区间：−1.43，−0.57）。抗阻运动对PWV和AIx没有影响。结合运动对PWV和AIx没有显著影响。
我们得出结论，有氧运动显著改善动脉僵硬度，且在有氧运动强度较高以及基线时动脉僵硬度较大的参与者中，这种效果更明显。
数据库注册号：CRD42014009744
Physical activity is associated with lower cardiovascular and all-cause mortality. However, the effects of different exercise modalities on arterial stiffness are currently unclear. Our objectives were to investigate the effects of exercise modalities (aerobic, resistance or combined) on pulse wave velocity (PWV) and augmentation index (AIx), and to determine whether the effects on these indices differed according to the participants' or exercise characteristics. We searched the Medline, Embase and Cochrane Library databases from inception until April 2014 for randomized controlled trials lasting ≥4 weeks investigating the effects of exercise modalities on PWV and AIx in adults aged ≥18 years. Forty-two studies (1627 participants) were included in this analysis. Aerobic exercise improved both PWV (WMD: −0.63 m/s, 95% CI: −0.90, −0.35) and AIx (WMD:−2.63%, 95% CI: −5.25 to −0.02) significantly. Aerobic exercise training showed significantly greater reduction in brachial-ankle (WMD: −1.01 m/s, 95% CI: −1.57, −0.44) than in carotid-femoral (WMD: -0.39 m/s, 95% CI: −0.52, −0.27) PWV. Higher aerobic exercise intensity was associated with larger reductions in AIx (β: −1.55%, CI −3.09, 0.0001). In addition, aerobic exercise had a significantly larger effect in reducing PWV (WMD:−1.0 m/s, 95% CI: −1.43, −0.57) in participants with stiffer arteries (PWV ≥8 m/s). Resistance exercise had no effect on PWV and AIx. There was no significant effect of combined exercise on PWV and AIx. We conclude that aerobic exercise improved arterial stiffness significantly and that the effect was enhanced with higher aerobic exercise intensity and in participants with greater arterial stiffness at baseline. Database registration: CRD42014009744,.
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