An evaluation of the left-brain vs. right-brain hypothesis with resting state functional connectivity magnetic resonance imaging.
An evaluation of the left-brain vs. right-brain hypothesis with resting state functional connectivity magnetic resonance imaging.
复制标题
对左脑和右脑假说的评估，并具有静止状态功能连通性磁共振成像。
DOI：
10.1371/journal.pone.0071275
复制
发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Anderson JS
中科院分区：
文献类型：
--
作者：
Nielsen JA;Zielinski BA;Ferguson MA;Lainhart JE;Anderson JS
侧化的大脑区域支持语言和视觉空间处理等功能。人们一直推测，根据个性和认知方式，个体可能是左脑优势或右脑优势，但神经影像学数据并没有提供明确的证据，证明是否存在这种左脑优势或右脑优势网络强度的表型差异。我们评估了强侧化连接是否在同一个体内共变。研究人员分析了1011名年龄在7岁至29岁之间的人的静息状态扫描数据。对于每个受试者，以5毫米分辨率测量覆盖灰质的每对7266个区域的功能侧化，作为在中矢状面反转图像前后的相关性差异。利用同位坐标间灰质密度的差异作为回归量来减少结构不对称对功能侧化的影响。从显著侧化连接图的度图中确定了9个左侧化枢纽和11个右侧化枢纽为峰值。左侧中枢包括来自默认模式网络的区域（内侧前额叶皮层、后扣带皮层和颞顶叶交界处）和语言区域（如布罗卡区和韦尼克区），而右侧中枢包括来自注意控制网络的区域（如外侧顶叶内沟、前岛、MT区和额视野）。左右侧化枢纽形成了两个可分离的相互侧化区域网络。只涉及左侧中枢或只涉及右侧中枢的连接在受试者之间显示出正相关，但仅适用于共享一个节点的连接。大脑连接的偏侧化似乎是大脑网络的局部特性，而不是全局特性，我们的数据与个体中更大的“左脑”或更大的“右脑”网络强度的全脑表型不一致。随着年龄的增长，偏侧性略有增加，但在性别上没有观察到差异。
Lateralized brain regions subserve functions such as language and visuospatial processing. It has been conjectured that individuals may be left-brain dominant or right-brain dominant based on personality and cognitive style, but neuroimaging data has not provided clear evidence whether such phenotypic differences in the strength of left-dominant or right-dominant networks exist. We evaluated whether strongly lateralized connections covaried within the same individuals. Data were analyzed from publicly available resting state scans for 1011 individuals between the ages of 7 and 29. For each subject, functional lateralization was measured for each pair of 7266 regions covering the gray matter at 5-mm resolution as a difference in correlation before and after inverting images across the midsagittal plane. The difference in gray matter density between homotopic coordinates was used as a regressor to reduce the effect of structural asymmetries on functional lateralization. Nine left- and 11 right-lateralized hubs were identified as peaks in the degree map from the graph of significantly lateralized connections. The left-lateralized hubs included regions from the default mode network (medial prefrontal cortex, posterior cingulate cortex, and temporoparietal junction) and language regions (e.g., Broca Area and Wernicke Area), whereas the right-lateralized hubs included regions from the attention control network (e.g., lateral intraparietal sulcus, anterior insula, area MT, and frontal eye fields). Left- and right-lateralized hubs formed two separable networks of mutually lateralized regions. Connections involving only left- or only right-lateralized hubs showed positive correlation across subjects, but only for connections sharing a node. Lateralization of brain connections appears to be a local rather than global property of brain networks, and our data are not consistent with a whole-brain phenotype of greater “left-brained” or greater “right-brained” network strength across individuals. Small increases in lateralization with age were seen, but no differences in gender were observed.
登录
查看更多内容
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
影响因子：
5.7
作者：
Fletcher, P. Thomas;Whitaker, Ross T.;Tao, Ran;DuBray, Molly B.;Froehlich, Alyson;Ravichandran, Caitlin;Alexander, Andrew L.;Bigler, Erin D.;Lange, Nicholas;Lainhart, Janet E.
通讯作者：
Lainhart, Janet E.
影响因子：
2.5
作者：
Andrews-Hanna, Jessica R.;Reidler, Jay S.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
影响因子：
2.6
作者：
Iwabuchi, Sarina J.;Haeberling, Isabelle S.;Kirk, Ian J.
通讯作者：
Kirk, Ian J.