Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism.
Microstructural connectivity of the arcuate fasciculus in adolescents with high-functioning autism.
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DOI：
10.1016/j.neuroimage.2010.01.083
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发表时间：
2010-07-01
期刊：
影响因子：
5.7
通讯作者：
Lainhart, Janet E.
中科院分区：
文献类型：
--
作者：
Fletcher, P. Thomas;Whitaker, Ross T.;Tao, Ran;DuBray, Molly B.;Froehlich, Alyson;Ravichandran, Caitlin;Alexander, Andrew L.;Bigler, Erin D.;Lange, Nicholas;Lainhart, Janet E.
弓状束是一种在语言中具有重要作用的白色纤维束。在这项研究中，扩散张量成像（DTI）被用来推断一组高功能自闭症受试者和一组年龄、惯用手、智商和头部大小相匹配的对照组的弓状束中白色物质的完整性。使用新的容积DTI分割算法从成像数据中自动提取每个受试者的弓状神经束。结果显示，自闭症组的平均扩散率（MD）显著增加，主要是由于径向扩散率（RD）的增加。DTI测量的偏侧化测试表明，自闭症组的MD和各向异性分数（FA）偏侧化程度较低。这些结果表明，白色物质的微结构在弓状束的自闭症和语言专业化明显的健康受试者的左弓状在自闭症中并不明显，这可能与较差的语言功能。
The arcuate fasciculus is a white matter fiber bundle of great importance in language. In this study, diffusion tensor imaging (DTI) was used to infer white matter integrity in the arcuate fasciculi of a group of subjects with high-functioning autism and a control group matched for age, handedness, IQ, and head size. The arcuate fasciculus for each subject was automatically extracted from the imaging data using a new volumetric DTI segmentation algorithm. The results showed a significant increase in mean diffusivity (MD) in the autism group, due mostly to an increase in the radial diffusivity (RD). A test of the lateralization of DTI measurements showed that both MD and fractional anisotropy (FA) were less lateralized in the autism group. These results suggest that white matter microstructure in the arcuate fasciculus is affected in autism and that the language specialization apparent in the left arcuate of healthy subjects is not as evident in autism, which may be related to poorer language functioning.
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