Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery.
Mesenchymal stem cell-based cell engineering with multifunctional mesoporous silica nanoparticles for tumor delivery.
复制标题
基于间充质干细胞的细胞工程，具有用于肿瘤递送的多功能介孔二氧化硅纳米粒子。
DOI：
10.1016/j.biomaterials.2012.11.032
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发表时间：
2013-02
期刊：
影响因子：
14
通讯作者：
Chen, Xiaoyuan
中科院分区：
文献类型：
--
作者：
Huang, Xinglu;Zhang, Fan;Wang, Hui;Niu, Gang;Choi, Ki Young;Swierczewska, Magdalena;Zhang, Guofeng;Gao, Haokao;Wang, Zhe;Zhu, Lei;Choi, Hak Soo;Lee, Seulki;Chen, Xiaoyuan
关键词：
Stem cell engineering, the manipulation and control of cells, harnesses tremendous potential for diagnosis and therapy of disease; however, it is still challenging to impart multifunctionalization onto stem cells to achieve both. Here we describe a mesenchymal stem cell (MSC)-based multifunctional platform to target orthotopic glioblastoma by integrating the tumor targeted delivery of mesenchymal stem cells and the multimodal imaging advantage of mesoporous silica nanoparticles (MSNs). Rapid cellular uptake, long retention time and stability of particles exemplify the potential that the combination of MSNs and MSCs has as a stem cell-based multifunctional platform. Using such a platform, we verified tumor-targeted delivery of MSCs by in vivo multimodal imaging in an orthotopic U87MG glioblastoma model, displaying higher tumor uptake than particles without MSCs. As a proof-of-concept, this MSC platform opens a new vision for multifunctional applications of cell products by combining the superiority of stem cells and nanoparticles for actively targeted delivery.
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影响因子：
17.1
作者：
Cheng H;Kastrup CJ;Ramanathan R;Siegwart DJ;Ma M;Bogatyrev SR;Xu Q;Whitehead KA;Langer R;Anderson DG
通讯作者：
Anderson DG
影响因子：
13.3
作者：
Ferris, Daniel P.;Lu, Jie;Gothard, Chris;Yanes, Rolando;Thomas, Courtney R.;Olsen, John-Carl;Stoddart, J. Fraser;Tamanoi, Fuyuhiko;Zink, Jeffrey I.
通讯作者：
Zink, Jeffrey I.
影响因子：
12.4
作者：
Liu S;Liu H;Ren G;Kimura RH;Cochran JR;Cheng Z
通讯作者：
Cheng Z
影响因子：
10.8
作者：
Bardhan R;Chen W;Bartels M;Perez-Torres C;Botero MF;McAninch RW;Contreras A;Schiff R;Pautler RG;Halas NJ;Joshi A
通讯作者：
Joshi A
影响因子：
10.8
作者：
Lin X;Xie J;Niu G;Zhang F;Gao H;Yang M;Quan Q;Aronova MA;Zhang G;Lee S;Leapman R;Chen X
通讯作者：
Chen X