Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes?
Does disruption of circadian rhythms contribute to beta-cell failure in type 2 diabetes?
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DOI：
10.1007/s11892-014-0474-4
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发表时间：
2014-04
影响因子：
4.2
通讯作者：
Matveyenko, Aleksey V.
中科院分区：
文献类型：
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作者：
Rakshit, Kuntol;Thomas, Anthony P.;Matveyenko, Aleksey V.
关键词：
2型糖尿病（T2 DM）是一种以β细胞分泌功能和质量丧失为特征的复杂代谢性疾病。T2 DM中β细胞衰竭的病理生理学涉及遗传易感性和环境风险因素之间的复杂相互作用。作为T2 DM的风险因素，一种越来越受到重视的环境条件是昼夜节律的破坏（例如轮班工作和睡眠不足）。近年来，昼夜节律紊乱在现代社会中越来越普遍，并一直显示出增加T2 DM易感性（部分通过其对胰腺β细胞的影响介导）。由于β-细胞衰竭对于2型糖尿病的发展至关重要，我们将从流行病学、临床和动物研究中回顾目前的工作，旨在深入了解与昼夜节律紊乱相关的β-细胞衰竭易感性的分子和生理机制。阐明生物钟在调节β细胞健康中的作用将增加我们对T2 DM病理生理学的理解，并可能有助于开发新的治疗和预防方法。
Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by the loss of beta-cell secretory function and mass. The pathophysiology of beta-cell failure in T2DM involves a complex interaction between genetic susceptibilities and environmental risk factors. One environmental condition that is gaining greater appreciation as a risk factor for T2DM is the disruption of circadian rhythms (eg, shift-work and sleep loss). In recent years, circadian disruption has become increasingly prevalent in modern societies and consistently shown to augment T2DM susceptibility (partly mediated through its effects on pancreatic beta-cells). Since beta-cell failure is essential for development of T2DM, we will review current work from epidemiologic, clinical, and animal studies designed to gain insights into the molecular and physiological mechanisms underlying the predisposition to beta-cell failure associated with circadian disruption. Elucidating the role of circadian clocks in regulating beta-cell health will add to our understanding of T2DM pathophysiology and may contribute to the development of novel therapeutic and preventative approaches.
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影响因子：
7.7
作者：
Buxton OM;Pavlova M;Reid EW;Wang W;Simonson DC;Adler GK
通讯作者：
Adler GK
影响因子：
10.5
作者：
Kondratov, Roman V.;Kondratova, Anna A.;Antoch, Marina P.
通讯作者：
Antoch, Marina P.
DOI：
10.1152/ajpendo.1996.271.2.e246
发表时间：
1996-08-01
影响因子：
5.1
作者：
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通讯作者：
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DOI：
10.1126/science.1195027
发表时间：
2010-12-03
期刊：
Science (New York, N.Y.)
影响因子：
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作者：
Bass J;Takahashi JS
通讯作者：
Takahashi JS
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影响因子：
30.8
作者：
通讯作者：
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