The effects of exercise during pregnancy on the newborn's brain: study protocol for a randomized controlled trial.
The effects of exercise during pregnancy on the newborn's brain: study protocol for a randomized controlled trial.
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怀孕期间运动对新生儿大脑的影响：随机对照试验的研究方案。
DOI：
10.1186/1745-6215-13-68
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发表时间：
2012-05-29
期刊：
影响因子：
2.5
通讯作者：
Ellemberg D
中科院分区：
文献类型：
--
作者：
LeMoyne EL;Curnier D;St-Jacques S;Ellemberg D
人们普遍认为，积极的生活方式有利于儿童、成人和老年人的认知。最近，使用大鼠动物模型的研究发现，在怀孕期间锻炼的母亲的幼崽增加了海马神经发生，记忆力和学习能力更好。本报告的目的是介绍一项研究的实验方案，该研究旨在验证人类怀孕期间积极的生活方式是否会对新生儿的大脑产生影响。60名孕妇将被纳入一项随机对照研究。实验组将被要求每周锻炼三次，每次至少20分钟，最低强度为最大有氧能力的55%。对照组不进行锻炼。在产后8至12天，将通过失配负波（一种与听觉感觉记忆相关的神经生理学脑电位）研究妊娠期间运动对新生儿大脑的影响。我们假设，母亲在怀孕期间行使所生的孩子将呈现更短的潜伏期和更大的不匹配负振幅，表明更有效的听觉记忆过程。截至2011年9月，已有17名妇女参加了这项研究。初步结果显示，实验组每周活动3.1 ± 0.9天，而对照组每周仅锻炼0.8 ± 0.6天。这项研究的结果将提供对胎儿神经可塑性的见解，并将成为希望鼓励孕妇锻炼的卫生专业人员的宝贵工具。ClinicalTrials.gov注册：NTC01220778
It is generally accepted that an active lifestyle is beneficial for cognition in children, adults and the elderly. Recently, studies using the rat animal model found that the pups of mothers who exercised during pregnancy had increased hippocampal neurogenesis and better memory and learning abilities. The aim of this report is to present the experimental protocol of a study that is designed to verify if an active lifestyle during pregnancy in humans has an impact on the newborn's brain. 60 pregnant women will be included in a randomized controlled study. The experimental group will be asked to exercise a minimum of 20 minutes three times per week, at a minimal intensity of 55% of their maximal aerobic capacity. The control group will not be exercising. The effect of exercise during pregnancy on the newborn's brain will be investigated 8 to 12 days postpartum by means of the mismatch negativity, a neurophysiological brain potential that is associated to auditory sensory memory. We hypothesize that children born to mothers who exercised during their pregnancy will present shorter latencies and larger mismatch negativity amplitudes, indicating more efficient auditory memory processes. As of September 2011, 17 women have joined the study. Preliminary results show that the experimental group are active 3.1 ± 0.9 days per week while the control group only exercise 0.8 ± 0.6 days per week. The results of this study will present insight on fetal neuroplasticity and will be a valuable tool for health professionals who wish to encourage pregnant women to exercise. ClinicalTrials.gov registration: NTC01220778
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DOI：
10.1093/geronb/gbq004
发表时间：
2010-05-01
影响因子：
6.2
作者：
Renaud, Melanie;Bherer, Louis;Maquestiaux, Francois
通讯作者：
Maquestiaux, Francois
DOI：
10.1016/s0926-6410(01)00093-3
发表时间：
2002-02-01
期刊：
COGNITIVE BRAIN RESEARCH
影响因子：
--
作者：
Ceponiene, R;Kushnerenko, E;Näätänen, R
通讯作者：
Näätänen, R
DOI：
10.1249/00005768-198205000-00012
发表时间：
1982-01-01
期刊：
MEDICINE AND SCIENCE IN SPORTS AND EXERCISE
影响因子：
--
作者：
BORG, GAV
通讯作者：
BORG, GAV
DOI：
10.1016/s0002-9378(98)70444-2
发表时间：
1998-03-01
影响因子：
9.8
作者：
Clapp, JF;Simonian, S;Harcar-Sevcik, R
通讯作者：
Harcar-Sevcik, R
影响因子：
5.1
作者：
Clapp, JF
通讯作者：
Clapp, JF