The link between allergies and eosinophilic esophagitis: implications for management strategies.
The link between allergies and eosinophilic esophagitis: implications for management strategies.
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DOI：
10.1586/eci.09.74
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发表时间：
2010-01
影响因子：
4.4
通讯作者：
Spergel JM
中科院分区：
文献类型：
--
作者：
Brown-Whitehorn TF;Spergel JM
嗜酸性粒细胞性食管炎（EE）的诊断与其他特应性疾病相似，发病率增加。我们对特应性疾病（即哮喘、过敏性鼻炎和特应性皮炎）和EE之间的共同特征进行了最近的文献综述。所有这些疾病都有过敏原触发和疾病部位可能存在Th2炎症的证据。小鼠模型也显示出T细胞和Th2细胞因子对疾病发展的重要性的类似特征。哮喘和EE中TGF-β表达增加，这些疾病都有潜在的炎症和重塑的潜力。然而，两种疾病在治疗和发病机制上确实存在差异。对于情感表达，有两种基本的治疗选择：避免食物触发或用皮质类固醇治疗嗜酸性粒细胞炎症。
Eosinophilic esophagitis (EE) has an increased incidence of diagnosis similar to other atopic diseases. We present a recent literature review of the common features between atopic diseases (i.e., asthma, allergic rhinitis and atopic dermatitis) and EE. All of the disorders have allergen triggers and evidence of a possible Th2 inflammation at the site of disease. Murine models have also shown similar features with the importance of T cells and Th2 cytokines for the development of disease. The diseases share underlying inflammation with the potential for remodeling with an increase in TGF-β expression in asthma and EE. However, differences do exist between the diseases in treatment and pathogenesis. For EE, there are two basic treatment options: avoidance of the food triggers or treatment of the eosinophilic inflammation with corticosteroids.
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影响因子：
12.6
作者：
Franciosi, James P.;Tam, Vicky;Spergel, Jonathan M.
通讯作者：
Spergel, Jonathan M.
影响因子：
29.4
作者：
Akei, HS;Mishra, A;Rothenberg, ME
通讯作者：
Rothenberg, ME
影响因子：
24.5
作者：
Attwood, SEA;Lewis, CJ;Whittam, J
通讯作者：
Whittam, J
影响因子：
9.8
作者：
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通讯作者：
Lim, JR
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8
作者：
Brim, Susan N.;Rudd, Rose A.;Callahan, David B.
通讯作者：
Callahan, David B.