Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity.
Cross-Talk between PPARgamma and Insulin Signaling and Modulation of Insulin Sensitivity.
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DOI：
10.1155/2009/818945
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发表时间：
2009
期刊：
影响因子：
2.9
通讯作者：
Giorgino F
中科院分区：
文献类型：
--
作者：
Leonardini A;Laviola L;Perrini S;Natalicchio A;Giorgino F
2型糖尿病患者中的PPARγ激活导致胰岛素和葡萄糖参数的显著改善，这是由于全身胰岛素敏感性的改善。脂肪组织是PPARγ影响胰岛素敏感性的主要介质。成熟脂肪细胞中的PPARγ活化诱导参与胰岛素信号级联的许多基因的表达，从而改善胰岛素敏感性。PPARγ是脂肪生成的主要调节因子，从而刺激小的胰岛素敏感性脂肪细胞的产生。除了其在脂肪形成中的重要性之外，PPARγ通过增加脂肪酸捕获而在成熟脂肪细胞中调节脂质代谢中起重要作用。最后，脂肪组织产生几种调节能量稳态、脂质和葡萄糖代谢的细胞因子。这些因子产生的紊乱可能导致代谢异常，并且PPARγ活化也与对整个范围的细胞因子的表达和分泌的有益作用相关。
PPARγ activation in type 2 diabetic patients results in a marked improvement in insulin and glucose parameters, resulting from an improvement of whole-body insulin sensitivity. Adipose tissue is the major mediator of PPARγ action on insulin sensitivity. PPARγ activation in mature adipocytes induces the expression of a number of genes involved in the insulin signaling cascade, thereby improving insulin sensitivity. PPARγ is the master regulator of adipogenesis, thereby stimulating the production of small insulin-sensitive adipocytes. In addition to its importance in adipogenesis, PPARγ plays an important role in regulating lipid, metabolism in mature adipocytes by increasing fatty acid trapping. Finally, adipose tissue produces several cytokines that regulate energy homeostasis, lipid and glucose metabolism. Disturbances in the production of these factors may contribute to metabolic abnormalities, and PPARγ activation is also associated with beneficial effects on expression and secretion of a whole range of cytokines.
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影响因子：
5.1
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