Factors impacting technical success rate of image-guided intra-arterial therapy in rat orthotopic liver tumor model.
Factors impacting technical success rate of image-guided intra-arterial therapy in rat orthotopic liver tumor model.
复制标题
影响大鼠原位肝肿瘤模型图像引导动脉内治疗技术成功率的因素。
DOI：
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发表时间：
2019
影响因子：
2.2
通讯作者：
R. Avritscher
中科院分区：
文献类型：
--
作者：
H. Nishiofuku;A. Cortés;J. Ensor;Adeeb A. Minhaj;U. Polak;M. López;R. Kiefer;S. Hunt;K. Kichikawa;M. Hicks;T. Gade;R. Avritscher
经导管肝动脉化疗栓塞术（TACE）是目前中期肝细胞癌（HCC）患者的标准治疗方法。为了研究TACE对肿瘤免疫微环境的影响，需要免疫活性大鼠模型。本研究的目的是确定影响免疫活性原位大鼠肝脏模型肝动脉插管技术成功的因素。为此，91只Sprague-Dawley大鼠和83只F344大鼠采用经颈动脉途径进行经导管肝动脉栓塞，并分为非荷瘤组（n = 41）和荷瘤组（n = 133）。通过血管造影图像评价肝动脉分支的血管直径。在92%的荷瘤大鼠和68.3%的非荷瘤大鼠中实现了肝固有动脉（PHA）插管。我们发现PHA直径与两组动物的体重之间存在强正相关性（P < 0.005），与大鼠的品系无关。根据动物体重预测成功置入PHA导管的logistic回归模型结果表明，在体重≥ 250 g的荷瘤动物和> 308 g的非荷瘤大鼠中，成功置入PHA导管的可能性很大，灵敏度和特异性分别为91.3%和100.0%以及96.4%和92.3%。总之，插管时动物的体重是经导管动脉栓塞术技术成功的主要决定因素。在动物选择过程中熟悉这些技术因素将提高TACE技术成功率。
Transcatheter hepatic arterial chemoembolization (TACE) is the current standard of care for intermediate stage hepatocellular carcinoma (HCC) patients. To study the effects of TACE in the tumor immune microenvironment, an immunocompetent rat model is required. The purpose of this study was to determine factors influencing technical success during hepatic arterial catheterization in immunocompetent orthotopic rat liver models. To this end, 91 Sprague-Dawley and eighty-three F344 rats underwent transcatheter hepatic arterial embolization using a transcarotid approach and were divided into a non-tumor-bearing (n = 41) and tumor-bearing (n = 133) groups. Vascular diameters of the hepatic arterial branches were evaluated from angiographic images. Catheterization of the proper hepatic artery (PHA) was achieved in 92% of the tumor-bearing and 68.3% of the non-tumor-bearing rats. We found a strong positive association between the diameter of the PHA and animals' body weight in both groups (P < 0.005), independently of the rat's strain. Results of the logistic regression model predicting a successful catheter placement into the PHA according to the animal's weight indicate that successful PHA catheterization is likely to be achieved in tumor-bearing animals weighing ≥ 250 g and > 308 g in non-tumor-bearing rats, with a sensitivity and specificity of 91.3% and 100.0% and 96.4% and 92.3%, respectively. In conclusion, animal's body weight at the time of catheterization is the principal determinant of technical success for transcatheter arterial embolization. Familiarity with these technical factors during animal selection will improve TACE technical success rates.
DOI：
10.1016/j.jvir.2017.03.037
发表时间：
2017-07
期刊：
Journal of vascular and interventional radiology : JVIR
影响因子：
--
作者：
Kiefer RM;Hunt SJ;Pulido S;Pickup S;Furth EE;Soulen MC;Nadolski GJ;Gade TP
通讯作者：
Gade TP
影响因子：
14
作者：
Lee J;Gordon AC;Kim H;Park W;Cho S;Lee B;Larson AC;Rozhkova EA;Kim DH
通讯作者：
Kim DH