Vitamin K in hand osteoarthritis: results from a randomised clinical trial.
Vitamin K in hand osteoarthritis: results from a randomised clinical trial.
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DOI：
10.1136/ard.2008.094771
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发表时间：
2008-11
影响因子：
27.4
通讯作者：
Booth SL
中科院分区：
文献类型：
--
作者：
Neogi T;Felson DT;Sarno R;Booth SL
维生素K对骨骼和软骨有影响，以前的研究表明它与放射照相的骨关节炎有关。我们在一项随机对照试验中评估了维生素K对手部骨关节炎的影响。这是一项随机对照试验的辅助研究，评估叶绿醌补充剂（维生素K组）与安慰剂对老年人骨质流失和血管钙化的影响，而不考虑他们的维生素K水平。在最后3年的研究访问中，我们使用逻辑回归和治疗意向评估了维生素K与安慰剂对骨关节炎手部x线特征的影响，并将分析限制在基线维生素K浓度不足的亚组。这项辅助研究有378名参与者（维生素K组193名，安慰剂组185名）。维生素K的随机化对骨性关节炎的影像学结果没有影响。那些在基线时维生素K不足的人在随访时达到足够的浓度，关节间隙狭窄的趋势减少了47% （p = 0.02）。维生素K对放射照相手骨关节炎没有总体影响。基线时维生素K含量不足的受试者在随访时达到足够的浓度可能对关节间隙缩小有好处。对维生素K缺乏的人进行临床试验可能是有必要的。NCT00183001。
Vitamin K has bone and cartilage effects, and previously shown to be associated with radiographic osteoarthritis. We evaluated vitamin K's effect on hand osteoarthritis in a randomised controlled trial. This was an ancillary study to a randomised controlled trial assessing the effects of phylloquinone supplementation (vitamin K arm) versus placebo on bone loss and vascular calcification among older adults regardless of their vitamin K status. At the final 3-year study visit, we assessed the effects of vitamin K versus placebo on hand x-ray features of osteoarthritis using logistic regression and intention to treat, and also restricted analysis to the subgroup that had insufficient vitamin K concentrations at baseline. This ancillary study had 378 participants (193 in vitamin K arm, 185 in placebo arm). There were no effects of randomisation to vitamin K for radiographic osteoarthritis outcomes. Those with insufficient vitamin K at baseline who attained sufficient concentrations at follow-up had trends towards 47% less joint space narrowing (p = 0.02). There was no overall effect of vitamin K on radiographic hand osteoarthritis. Subjects that were insufficient in vitamin K at baseline who attained sufficient concentrations at follow-up may have had a benefit in joint space narrowing. A clinical trial in those who are vitamin K insufficient may be warranted. NCT00183001.
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影响因子：
4.2
作者：
Booth, SL;Suttie, JW
通讯作者：
Suttie, JW
影响因子：
4.1
作者：
Bischoff-Ferrari, Heike Annette;Dawson-Hughes, Bess
通讯作者：
Dawson-Hughes, Bess
影响因子：
--
作者：
Loeser, RF;Varnum, BC;Wallin, R
通讯作者：
Wallin, R
影响因子：
39.2
作者：
McAlindon, TE;Felson, DT;Jacques, P
通讯作者：
Jacques, P
影响因子：
2.9
作者：
Price, P A
通讯作者：
Price, P A