A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.
A single dose of the SARS-CoV-2 vaccine BNT162b2 elicits Fc-mediated antibody effector functions and T cell responses.
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DOI：
10.1016/j.chom.2021.06.001
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发表时间：
2021-07-14
影响因子：
30.3
通讯作者：
Finzi A
中科院分区：
文献类型：
--
作者：
Tauzin A;Nayrac M;Benlarbi M;Gong SY;Gasser R;Beaudoin-Bussières G;Brassard N;Laumaea A;Vézina D;Prévost J;Anand SP;Bourassa C;Gendron-Lepage G;Medjahed H;Goyette G;Niessl J;Tastet O;Gokool L;Morrisseau C;Arlotto P;Stamatatos L;McGuire AT;Larochelle C;Uchil P;Lu M;Mothes W;De Serres G;Moreira S;Roger M;Richard J;Martel-Laferrière V;Duerr R;Tremblay C;Kaufmann DE;Finzi A
虽然针对 SARS-CoV-2 的 BNT162b2 mRNA 疫苗的标准方案包括间隔 3 周注射两剂，但一些公共卫生当局正在间隔这些剂量，这引起了人们对功效的担忧。然而，数据表明，从给药后 14 天开始，单剂量的有效率可达 90%。为了评估有助于保护的机制，我们分析了单次 BNT162b2 剂量三周后的体液和 T 细胞反应。我们观察到，在 SARS-CoV-2 首次接触个体中，中和活性较弱，但抗受体结合域和刺突抗体具有较强的 Fc 介导的效应功能和细胞 CD4+ T 细胞反应。在之前感染过的个体中，单剂量即可增强所有体液和 T 细胞反应，并且 T 辅助细胞和抗体免疫之间具有很强的相关性。我们的结果强调了 Fc 介导的效应器功能和 T 细胞反应在疫苗功效中的潜在作用。他们还为间隔剂量提供支持，以便在疫苗短缺的情况下为更多的人接种疫苗。陶津和奈拉克等人。描述单剂 mRNA BNT162b2 疫苗后 3 周的体液和细胞反应特征。他们表明，在未接触过 SARS-CoV-2 的个体中，引发的抗体具有较弱的中和活性，但具有强大的 Fc 介导的效应功能，而在之前感染过 SARS-CoV-2 的个体中，所有反应均显着增强。
While the standard regimen of the BNT162b2 mRNA vaccine for SARS-CoV-2 includes two doses administered 3 weeks apart, some public health authorities are spacing these doses, raising concerns about efficacy. However, data indicate that a single dose can be up to 90% effective starting 14 days post-administration. To assess the mechanisms contributing to protection, we analyzed humoral and T cell responses three weeks after a single BNT162b2 dose. We observed weak neutralizing activity elicited in SARS-CoV-2 naive individuals but strong anti-receptor binding domain and spike antibodies with Fc-mediated effector functions and cellular CD4+ T cell responses. In previously infected individuals, a single dose boosted all humoral and T cell responses, with strong correlations between T helper and antibody immunity. Our results highlight the potential role of Fc-mediated effector functions and T cell responses in vaccine efficacy. They also provide support for spacing doses to vaccinate more individuals in conditions of vaccine scarcity. Tauzin and Nayrac et al. characterize humoral and cellular responses 3 weeks after a single dose of mRNA BNT162b2 vaccine. They show, in SARS-CoV-2-naive individuals, that the antibodies elicited have weak neutralizing activity but potent Fc-mediated effector functions, and in SARS-CoV-2 previously infected individuals, that all responses are significantly boosted.
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DOI：
10.1056/nejmoa2035389
发表时间：
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影响因子：
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