Caenorhabditis elegans as a model for intracellular pathogen infection.
Caenorhabditis elegans as a model for intracellular pathogen infection.
复制标题
秀丽隐杆线虫作为细胞内病原体感染的模型。
DOI：
10.1111/cmi.12152
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发表时间：
2013-08
影响因子：
3.4
通讯作者：
Troemel ER
中科院分区：
文献类型：
--
作者：
Balla KM;Troemel ER
The genetically tractable nematode Caenorhabditis elegans is a convenient host for studies of pathogen infection. With the recent identification of two types of natural intracellular pathogens of C. elegans, this host now provides the opportunity to examine interactions and defence against intracellular pathogens in a whole-animal model for infection. C. elegans is the natural host for a genus of microsporidia, which comprise a phylum of fungal-related pathogens of widespread importance for agriculture and medicine. More recently, C. elegans has been shown to be a natural host for viruses related to the Nodaviridae family. Both microsporidian and viral pathogens infect the C. elegans intestine, which is composed of cells that share striking similarities to human intestinal epithelial cells. Because C. elegans nematodes are transparent, these infections provide a unique opportunity to visualize differentiated intestinal cells in vivo during the course of intracellular infection. Together, these two natural pathogens of C. elegans provide powerful systems in which to study microbial pathogenesis and host responses to intracellular infection.
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影响因子：
30.8
作者：
Andersen, Erik C.;Gerke, Justin P.;Shapiro, Joshua A.;Crissman, Jonathan R.;Ghosh, Rajarshi;Bloom, Joshua S.;Felix, Marie-Anne;Kruglyak, Leonid
通讯作者：
Kruglyak, Leonid
影响因子：
5.4
作者：
Franz, Carl J.;Zhao, Guoyan;Wang, David
通讯作者：
Wang, David
影响因子：
2.8
作者：
Guha, Sujay;Klees, Miranda;Cao, Min
通讯作者：
Cao, Min
DOI：
10.1073/pnas.0506442103
发表时间：
2006-03-14
影响因子：
11.1
作者：
Liu, WH;Lin, YL;Liao, CL
通讯作者：
Liao, CL
影响因子：
6.7
作者：
Estes, Kathleen A.;Szumowski, Suzannah C.;Troemel, Emily R.
通讯作者：
Troemel, Emily R.