Low birth weight and residential proximity to PCB-contaminated waste sites.
Low birth weight and residential proximity to PCB-contaminated waste sites.
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DOI：
10.1289/ehp.6053
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发表时间：
2003-08
影响因子：
10.4
通讯作者：
Carpenter DO
中科院分区：
文献类型：
--
作者：
Baibergenova A;Kudyakov R;Zdeb M;Carpenter DO
先前的调查表明，接触多氯联苯（PCBs）的妇女生下低出生体重（< 2500克）婴儿的风险增加，而且这种关系在男婴中比女婴更强。我们已经测试了一个假设，即居住在含有多氯联苯危险废物场的邮政编码地区或靠近被多氯联苯污染的水体的居民生下低出生体重婴儿的风险更高。我们使用纽约州生命统计的出生登记来确定1994年至2000年间在纽约州出生的所有人，除了纽约市。该注册表提供婴儿、母亲和父亲的信息以及母亲居住地的邮政编码。865个州超级基金遗址，86个国家优先名单遗址，以及纽约的6个关注区域都被划分为是否含有多氯联苯作为主要污染物。我们确定了187个包含或毗邻多氯联苯污染地点的邮政编码，这些邮政编码占945,077名新生儿的24.5%。出生体重在PCB邮政编码比其他邮政编码平均少21.6 g （p < 0.001）。由于低出生体重还有许多其他的危险因素，我们对这些混杂因素使用逻辑回归模型进行了调整。在调整了婴儿的性别、母亲的年龄、种族、体重、身高、教育程度、收入、婚姻状况和吸烟等因素后，生育低出生体重男婴的风险仍然增加了6%，这在统计学上是显著的。这些观察结果支持了一种假设，即居住在多氯联苯污染地点附近的邮政编码地区有接触多氯联苯的风险，并可能生出出生体重过低的婴儿。
Previous investigations have shown that women exposed to polychlorinated biphenyls (PCBs) are at increased risk of giving birth to an infant with low birth weight (< 2,500 g), and that this relationship is stronger for male than for female infants. We have tested the hypothesis that residents in a zip code that contains a PCB hazardous waste site or abuts a body of water contaminated with PCBs are at increased risk of giving birth to a low-birth-weight baby. We used the birth registry of the New York State Vital Statistics to identify all births between 1994 and 2000 in New York State except for New York City. This registry provides information on the infant, mother, and father together with the zip code of the mother's residence. The 865 state Superfund sites, the 86 National Priority List sites, and the six Areas of Concern in New York were characterized regarding whether or not they contain PCBs as a major contaminant. We identified 187 zip codes containing or abutting PCB-contaminated sites, and these zip codes were the residences of 24.5% of the 945,077 births. The birth weight in the PCB zip codes was on average 21.6 g less than in other zip codes (p < 0.001). Because there are many other risk factors for low birth weight, we have adjusted for these using a logistic regression model for these confounders. After adjusting for sex of the infant, mother's age, race, weight, height, education, income, marital status, and smoking, there was still a statistically significant 6% increased risk of giving birth to a male infant of low birth weight. These observations support the hypothesis that living in a zip code near a PCB-contaminated site poses a risk of exposure and giving birth to an infant of low birth weight.
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影响因子：
4.6
作者：
JACOBSON, SW;FEIN, GG;DOWLER, JK
通讯作者：
DOWLER, JK
DOI：
10.1111/j.1440-1754.1994.tb00657.x
发表时间：
1994-08-01
影响因子：
1.7
作者：
HERCEG, A;SIMPSON, JM;THOMPSON, JF
通讯作者：
THOMPSON, JF
影响因子：
10.4
作者：
Berry M;Bove F
通讯作者：
Bove F
影响因子：
7.1
作者：
HASTE, FM;BROOKE, OG;PEACOCK, JL
通讯作者：
PEACOCK, JL
影响因子：
10.4
作者：
Gilbertson, M;Brophy, J
通讯作者：
Brophy, J