Late-life depression, mild cognitive impairment and hippocampal functional network architecture.
Late-life depression, mild cognitive impairment and hippocampal functional network architecture.
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DOI：
10.1016/j.nicl.2013.09.002
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发表时间：
2013
影响因子：
4.2
通讯作者：
Goveas, Joseph S.
中科院分区：
文献类型：
--
作者：
Xie, Chunming;Li, Wenjun;Chen, Gang;Ward, B. Douglas;Franczak, Malgorzata B.;Jones, Jennifer L.;Antuono, Piero G.;Li, Shi-Jiang;Goveas, Joseph S.
关键词：
老年抑郁症(LLD)和遗忘性轻度认知障碍(AMCI)与内侧颞叶结构异常相关。然而，当这些综合征单独发生或共存时，与这些综合征相关的海马区功能连接(HFC)的异同尚不清楚。采用静息功能连接性磁共振成像(R-fMRI)技术对72例老年受试者(LLD[n=18]、aMCI[n=17]、LLD合并aMCI[n=12]和健康对照组[n=25])进行左、右HFC测量。在控制了年龄、性别、教育程度和灰质体积后，确定了LLD和aMCI在HFC网络上的主要和交互关系。抑郁症状和情景记忆缺陷对海马区功能连接的影响也被评估。虽然左右HFC的增加和减少以及参与情绪调节的几个皮质和皮质下结构与LLD有关，但aMCI与整体连接性降低有关。在右侧HFC网络上，LLD-aMCI的显著交互作用出现在对情绪处理和高阶认知功能至关重要的大脑区域。在相互作用的脑区，LLD和aMCI与海马区功能连接减弱有关，而共病组表现出连接增强。抑郁症状和情景记忆表现的主要和交互作用也与双侧HFC网络异常有关。总之，这些发现表明，当LLD和aMCI单独发生时，离散的海马区功能网络异常与LLD和aMCI相关。然而，当这些情况并存时，海马体网络会出现更明显的脆弱性，这可能是疾病严重程度和即将到来的认知能力下降的标志。通过利用R-fMRI技术，本研究在功能网络水平上对LLD和aMCI的神经机制提供了新的见解。用R-fMRI研究老年抑郁症和MCI对海马区记忆网络的影响不同的海马区功能网络与老年抑郁症和MCI相关。老年抑郁症与MCI在海马区功能网络水平上存在交互作用。海马区功能网络与神经心理测量相关。对抑郁症和MCI背后的功能网络脆弱性的新见解
Late-life depression (LLD) and amnestic mild cognitive impairment (aMCI) are associated with medial temporal lobe structural abnormalities. However, the hippocampal functional connectivity (HFC) similarities and differences related to these syndromes when they occur alone or coexist are unclear. Resting-state functional connectivity MRI (R-fMRI) technique was used to measure left and right HFC in 72 elderly participants (LLD [n = 18], aMCI [n = 17], LLD with comorbid aMCI [n = 12], and healthy controls [n = 25]). The main and interactive relationships of LLD and aMCI on the HFC networks were determined, after controlling for age, gender, education and gray matter volumes. The effects of depressive symptoms and episodic memory deficits on the hippocampal functional connections also were assessed. While increased and decreased left and right HFC with several cortical and subcortical structures involved in mood regulation were related to LLD, aMCI was associated with globally diminished connectivity. Significant LLD–aMCI interactions on the right HFC networks were seen in the brain regions critical for emotion processing and higher-order cognitive functions. In the interactive brain regions, LLD and aMCI were associated with diminished hippocampal functional connections, whereas the comorbid group demonstrated enhanced connectivity. Main and interactive effects of depressive symptoms and episodic memory performance were also associated with bilateral HFC network abnormalities. In conclusion, these findings indicate that discrete hippocampal functional network abnormalities are associated with LLD and aMCI when they occur alone. However, when these conditions coexist, more pronounced vulnerabilities of the hippocampal networks occur, which may be a marker of disease severity and impending cognitive decline. By utilizing R-fMRI technique, this study provides novel insights into the neural mechanisms underlying LLD and aMCI in the functional network level. Effects of late-life depression and MCI on hippocampal memory network using R-fMRI Distinct hippocampal functional network correlates in late-life depression and MCI. Late-life depression and MCI interact on hippocampal functional network level. Hippocampal functional network correlates with neuropsychological measures. Novel insights into functional network vulnerability underlying depression and MCI
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影响因子：
7.2
作者：
Aizenstein, Howard J.;Butters, Meryl A.;Wu, Minjie;Mazurkewicz, Laura M.;Stenger, V. Andrew;Gianaros, Peter J.;Becker, James T.;Reynolds, Cbarles F., III;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
3.7
作者：
Bai F;Xie C;Watson DR;Shi Y;Yuan Y;Wang Y;Yue C;Teng Y;Wu D;Zhang Z
通讯作者：
Zhang Z
DOI：
10.1176/appi.ajp.2011.10060853
发表时间：
2011-10
期刊：
The American journal of psychiatry
影响因子：
--
作者：
Aizenstein HJ;Andreescu C;Edelman KL;Cochran JL;Price J;Butters MA;Karp J;Patel M;Reynolds CF 3rd
通讯作者：
Reynolds CF 3rd
影响因子：
4.8
作者：
Birn, Rasmus M.;Murphy, Kevin;Bandettini, Peter A.
通讯作者：
Bandettini, Peter A.
影响因子：
2.1
作者：
Butters, Meryl A.;Klunk, William E.;Meltzer, Carolyn C.
通讯作者：
Meltzer, Carolyn C.