Exploitation of other social amoebae by Dictyostelium caveatum.
Exploitation of other social amoebae by Dictyostelium caveatum.
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DOI：
10.1371/journal.pone.0000212
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发表时间：
2007-02-14
期刊：
影响因子：
3.7
通讯作者：
Kessin RH
中科院分区：
文献类型：
--
作者：
Nizak C;Fitzhenry RJ;Kessin RH
面临饥饿的盘基网柄菌阿米巴会触发一个发育程序，在此过程中许多细胞聚集并形成子实体，子实体由细茎高举的孢子球组成。这种发育策略可用于多种形式的利用，包括盘基网柄菌（Dictyostelium Caveatum）的显着案例，即使它占细胞总数的 1/103，也可以抑制宿主的发育并最终吞噬它。我们证明，它通过抑制一个称为尖端的细胞区域来实现这一壮举，该区域组织聚集体发育成子实体。我们使用活细胞显微镜来定义 D.caveatum 发育周期，并表明 D.caveatum 变形虫具有摄取其他盘基网柄菌属变形虫的能力，但不会互相攻击。 D. Caveatum 诱导的发育受阻不会影响前孢子细胞或前茎细胞分化的特定标记物的表达，但会阻止导致尖端形成的协调细胞运动。抑制机制涉及 D. Caveatum 组成型分泌小分子，并且是可逆的。四种盘基网柄菌属物种的发育受到抑制，而盘基网柄菌则不受其自身化合物的抑制。 D. Caveatum 已经进化出一种捕食策略来利用其属的其他成员，包括发育抑制和特异性吞噬机制。
Dictyostelium amoebae faced with starvation trigger a developmental program during which many cells aggregate and form fruiting bodies that consist of a ball of spores held aloft by a thin stalk. This developmental strategy is open to several forms of exploitation, including the remarkable case of Dictyostelium caveatum, which, even when it constitutes 1/103 of the cells in an aggregate, can inhibit the development of the host and eventually devour it. We show that it accomplishes this feat by inhibiting a region of cells, called the tip, which organizes the development of the aggregate into a fruiting body. We use live-cell microscopy to define the D. caveatum developmental cycle and to show that D. caveatum amoebae have the capacity to ingest amoebae of other Dictyostelid species, but do not attack each other. The block in development induced by D. caveatum does not affect the expression of specific markers of prespore cell or prestalk cell differentiation, but does stop the coordinated cell movement leading to tip formation. The inhibition mechanism involves the constitutive secretion of a small molecule by D. caveatum and is reversible. Four Dictyostelid species were inhibited in their development, while D. caveatum is not inhibited by its own compound(s). D. caveatum has evolved a predation strategy to exploit other members of its genus, including mechanisms of developmental inhibition and specific phagocytosis.
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DOI：
10.1126/science.1130670
发表时间：
2006-10-27
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Schaap P;Winckler T;Nelson M;Alvarez-Curto E;Elgie B;Hagiwara H;Cavender J;Milano-Curto A;Rozen DE;Dingermann T;Mutzel R;Baldauf SL
通讯作者：
Baldauf SL
影响因子：
56.9
作者：
GOMER, RH;FIRTEL, RA
通讯作者：
FIRTEL, RA
DOI：
10.1007/s00359-005-0620-1
发表时间：
2005-06-01
影响因子：
2.1
作者：
Haspel, G;Gefen, E;Libersat, F
通讯作者：
Libersat, F
影响因子：
64.5
作者：
ABE, T;EARLY, A;WILLIAMS, J
通讯作者：
WILLIAMS, J
影响因子：
3.7
作者：
WADDELL, DR;VOGEL, G
通讯作者：
VOGEL, G