Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study.
Calcinosis is associated with digital ulcers and osteoporosis in patients with systemic sclerosis: A Scleroderma Clinical Trials Consortium study.
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DOI：
10.1016/j.semarthrit.2016.05.008
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发表时间：
2016-12
影响因子：
5
通讯作者：
Chung L
中科院分区：
文献类型：
--
作者：
Valenzuela A;Baron M;Canadian Scleroderma Research Group;Herrick AL;Proudman S;Stevens W;Australian Scleroderma Interest Group;Rodriguez-Reyna TS;Vacca A;Medsger TA Jr;Hinchcliff M;Hsu V;Wu JY;Fiorentino D;Chung L
我们与硬皮病临床试验联盟（SCTC）进行了一项国际多中心合作，试图确定与钙质沉着相关的临床因素。这是一项对5218例系统性硬化症（SSc）患者进行的回顾性队列研究。Logistic回归用于获得多变量分析中钙质沉着与各种临床特征相关的比值比（OR）。共有1290名患者（24.7%）患有钙质沉着症。在单变量分析中，钙质沉着症患者比无钙质沉着症患者年龄大，更可能是女性，并且从第一个非雷诺现象症状开始的疾病持续时间更长。钙质沉着症患者更容易出现指端溃疡、毛细血管扩张、肢端骨质溶解、心脏病、肺动脉高压、胃肠道受累、关节炎和骨质疏松症，但不太可能出现肌肉疾病。抗Scl-70、RNA聚合酶III和U1-RNP自身抗体在钙质沉着症患者中明显不常见，而抗着丝粒（ACA）、抗PM/Scl和抗心磷脂抗体更常见。在多变量分析中，与钙质沉着最强的相关性是指端溃疡（OR = 3.9; 95% CI：2.7-5.5; p < 0.0001）和骨质疏松症（OR = 4.2; 95% CI：2.3-7.9; p < 0.0001）。四分之一的SSc患者在患病期间的某个时间患有钙质沉着症。我们的数据证实了钙质沉着症与指端溃疡的强相关性，并支持与骨质疏松症的新相关性。
We sought to identify the clinical factors associated with calcinosis in an international multicenter collaborative effort with the Scleroderma Clinical Trials Consortium (SCTC). This is a retrospective cohort study of 5218 patients with systemic sclerosis (SSc). Logistic regression was used to obtain odds ratios (OR) relating calcinosis to various clinical features in multivariate analyses. A total of 1290 patients (24.7%) had calcinosis. In univariate analyses, patients with calcinosis were older than patients without calcinosis, more likely to be female, and had longer disease duration from the first non-Raynaud phenomenon symptom. Patients with calcinosis were more likely to have digital ulcers, telangiectasias, acro-osteolysis, cardiac disease, pulmonary hypertension, gastrointestinal involvement, arthritis, and osteoporosis, but less likely to have muscle disease. Anti-Scl-70, RNA-polymerase-III, and U1-RNP autoantibodies were significantly less common in patients with calcinosis, while anticentromere (ACA), anti-PM/Scl, and anticardiolipin antibodies were more frequent. In multivariate analysis, the strongest associations with calcinosis were digital ulcers (OR = 3.9; 95% CI: 2.7–5.5; p < 0.0001) and osteoporosis (OR = 4.2; 95% CI: 2.3–7.9; p < 0.0001). One quarter of patients with SSc have calcinosis at some time during their illness. Our data confirm a strong association of calcinosis with digital ulcers, and support a novel association with osteoporosis.
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影响因子：
27.4
作者：
Domsic RT;Rodriguez-Reyna T;Lucas M;Fertig N;Medsger TA Jr
通讯作者：
Medsger TA Jr
影响因子：
--
作者：
van den Hoogen, Frank;Khanna, Dinesh;Fransen, Jaap;Johnson, Sindhu R.;Baron, Murray;Tyndall, Alan;Matucci-Cerinic, Marco;Naden, Raymond P.;Medsger, Thomas A., Jr.;Carreira, Patricia E.;Riemekasten, Gabriela;Clements, Philip J.;Denton, Christopher P.;Distler, Oliver;Allanore, Yannick;Furst, Daniel E.;Gabrielli, Armando;Mayes, Maureen D.;van Laar, Jacob M.;Seibold, James R.;Czirjak, Laszlo;Steen, Virginia D.;Inanc, Murat;Kowal-Bielecka, Otylia;Mueller-Ladner, Ulf;Valentini, Gabriele;Veale, Douglas J.;Vonk, Madelon C.;Walker, Ulrich A.;Chung, Lorinda;Collier, David H.;Csuka, Mary Ellen;Fessler, Barri J.;Guiducci, Serena;Herrick, Ariane;Hsu, Vivien M.;Jimenez, Sergio;Kahaleh, Bashar;Merkel, Peter A.;Sierakowski, Stanislav;Silver, Richard M.;Simms, Robert W.;Varga, John;Pope, Janet E.
通讯作者：
Pope, Janet E.
影响因子：
--
作者：
Balin, Samuel J.;Wetter, David A.;Davis, Mark D. P.
通讯作者：
Davis, Mark D. P.
影响因子：
37.8
作者：
Fadini GP;Rattazzi M;Matsumoto T;Asahara T;Khosla S
通讯作者：
Khosla S
影响因子：
10.9
作者：
Valenzuela, Antonia;Chung, Lorinda;Casciola-Rosen, Livia;Fiorentino, David
通讯作者：
Fiorentino, David