Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease.
Potential Biological Effects of (-)-Epigallocatechin-3-gallate on the Treatment of Nonalcoholic Fatty Liver Disease.
复制标题
(-)-表没食子儿茶素-3-没食子酸酯治疗非酒精性脂肪肝的潜在生物学效应
DOI：
10.1002/mnfr.201700483
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发表时间：
2018-01
影响因子：
5.2
通讯作者：
Feng Q
中科院分区：
文献类型：
--
作者：
Chen C;Liu Q;Liu L;Hu YY;Feng Q
非酒精性脂肪肝（NAFLD）是全世界的一个主要健康问题。然而，目前尚无针对 NAFLD 的有效治疗方法。深入的研究证明了（‐）‐表没食子儿茶素‐3‐没食子酸酯（EGCG）（一种从绿茶中提取的主要生物活性化学物质）在治疗 NAFLD 方面的功效。 EGCG具有多管齐下的预防和治疗活性，包括促进脂质和葡萄糖代谢、抗脂质过氧化和抗炎活性、抗纤维化和抗NAFLD相关肿瘤，从而有助于减轻NAFLD的发生和进展。本文旨在综述和讨论目前已知的EGCG干扰NAFLD发病机制的靶点、信号通路和作用，为EGCG预防和治疗NAFLD的进一步研究和临床应用提供更多的实验证据和基础。
Nonalcoholic fatty liver disease (NAFLD) is a major health issue throughout the world. However, no validated treatments for NAFLD are currently available. In‐depth studies have demonstrated the efficacy of (‐)‐epigallocatechin‐3‐gallate (EGCG), a main bioactive chemical extracted from green tea, in treating NAFLD. EGCG exhibits multi‐pronged preventive and therapeutic activities, including promoting lipid and glucose metabolism, anti‐lipid peroxidation and anti‐inflammation activities, anti‐fibrosis, and anti‐NAFLD related tumor, thus contributing to the mitigation of NAFLD occurrence and progression. The objectives of this paper are to review and discuss the currently known targets, signaling pathways and roles of EGCG that interfere with NAFLD pathogenesis, then providing additional experimental evidence and the foundation for the further studies and clinical applications of EGCG in the prevention and treatment of NAFLD.
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DOI：
10.1093/jn/138.9.1677
发表时间：
2008-09
期刊：
The Journal of nutrition
影响因子：
--
作者：
Bose M;Lambert JD;Ju J;Reuhl KR;Shapses SA;Yang CS
通讯作者：
Yang CS
影响因子：
6.3
作者：
Hsu, Chung-Hua;Tsai, Tung-Hu;Chou, Pesus
通讯作者：
Chou, Pesus
影响因子：
6.1
作者：
Bursill, CA;Roach, PD
通讯作者：
Roach, PD
影响因子：
3
作者：
Haque, Rizwanul;Nazir, Aamir
通讯作者：
Nazir, Aamir
影响因子：
4.8
作者：
Henriksen BS;Curtis ME;Fillmore N;Cardon BR;Thomson DM;Hancock CR
通讯作者：
Hancock CR