Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology.
Convergence of VEGF and YAP/TAZ signaling: Implications for angiogenesis and cancer biology.
复制标题
DOI：
10.1126/scisignal.aau1165
复制
发表时间：
2018-10-16
影响因子：
7.3
通讯作者：
Mercurio AM
中科院分区：
文献类型：
--
作者：
Elaimy AL;Mercurio AM
血管内皮生长因子（VEGF）刺激内皮细胞，促进发育和病理性血管生成。它还靶向肿瘤细胞，特别是癌症干细胞（CSC），直接影响肿瘤的发生，进展和复发。最近的工作已经揭示了雅普/TAZ（转录共激活因子）在介导VEGF信号传导中的重要性。从这项工作中出现的一个主题是VEGF信号传导影响Rho家族GT3活性和细胞骨架动力学，这有助于雅普/TAZ活化，并且雅普/TAZ介导的转录变化维持Rho家族GT3活性和细胞骨架动力学，以影响内皮细胞中的血管生长和重塑以及肿瘤细胞中干细胞样性状的获得。这些发现是重要的，因为它们的病理生理学的重要性和它们的连接到其他受体介导的途径。这篇综述讨论了这些发现，并强调了未来的研究领域。血管内皮生长因子（VEGF）对于血管生成过程至关重要，包括发育过程中器官的血管化和新生肿瘤，从而促进其生长和传播。这些过程由内皮细胞上表达的VEGF受体介导。一些肿瘤细胞也表达VEGF受体，这些细胞中的VEGF信号传导与攻击性行为相关，包括获得干细胞样特征。了解VEGF如何影响内皮细胞和肿瘤细胞是一个至关重要的问题，因为抑制这种信号传导作为一种治疗策略的潜在益处。在这篇综述中，Elaimy和Mercurio描述了最近的工作，揭示了雅普和TAZ（Hippo通路中的转录效应子）在介导VEGF信号传导中的重要性。VEGF和雅普/TAZ信号传导的汇合导致转录和细胞骨架改变，其促进肿瘤细胞中的血管生成和干细胞样性状的获得。
Vascular endothelial growth factor (VEGF) stimulates endothelial cells to promote developmental and pathological angiogenesis. It also targets tumor cells, especially cancer stem cells (CSCs), to affect tumor initiation, progression and recurrence directly. Recent work has uncovered the importance of YAP/TAZ, transcriptional co-activators, in mediating VEGF signaling. One theme that has emerged from this work is that VEGF signaling impacts Rho family GTPase activity and cytoskeletal dynamics, which contribute to YAP/TAZ activation, and that YAP/TAZ-mediated transcriptional changes sustain Rho family GTPase activity and cytoskeletal dynamics to impact vascular growth and remodeling in endothelial cells and the acquisition of stem-like traits in tumor cells. These findings are significant because of their pathophysiological importance and their connection to other receptor-mediated pathways. This review discusses these findings and highlights areas for future study. Vascular endothelial growth factor (VEGF) is essential for angiogenic processes including the vascularization of organs during development and nascent tumors, which fuels their growth and dissemination. These processes are mediated by VEGF receptors expressed on endothelial cells. Some tumor cells also express VEGF receptors and VEGF signaling in these cells is associated with aggressive behavior, including the acquisition of stem-like traits. Understanding how VEGF impacts endothelial and tumor cells is a problem of paramount importance given the potential benefit of inhibiting this signaling as a therapeutic strategy. In this review with one figure and 60 references, Elaimy and Mercurio describe recent work revealing the importance of YAP and TAZ, transcriptional effectors in the Hippo pathway, in mediating VEGF signaling. The confluence of VEGF and YAP/TAZ signaling results in transcriptional and cytoskeletal alterations that promote angiogenesis and the acquisition of stem-like traits in tumor cells.
登录
查看更多内容
影响因子：
4
作者：
Goel, Hira Lal;Pursell, Bryan;Mercurio, Arthur M.
通讯作者：
Mercurio, Arthur M.
影响因子：
4.8
作者：
Kissil, JL;Johnson, KC;Jacks, T
通讯作者：
Jacks, T
影响因子：
11.1
作者：
Goel, Hira Lal;Pursell, Bryan;Chang, Cheng;Shaw, Leslie M.;Mao, Junhao;Simin, Karl;Kumar, Prashant;Vander Kooi, Craig W.;Shultz, Leonard D.;Greiner, Dale L.;Norum, Jens Henrik;Toftgard, Rune;Kuperwasser, Charlotte;Mercurio, Arthur M.
通讯作者：
Mercurio, Arthur M.
DOI：
10.1038/nrc2442
发表时间：
2008-08
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
16.6
作者：
Azad T;Janse van Rensburg HJ;Lightbody ED;Neveu B;Champagne A;Ghaffari A;Kay VR;Hao Y;Shen H;Yeung B;Croy BA;Guan KL;Pouliot F;Zhang J;Nicol CJB;Yang X
通讯作者：
Yang X