Meta-analysis of MMP2, MMP3, and MMP9 promoter polymorphisms and head and neck cancer risk.
Meta-analysis of MMP2, MMP3, and MMP9 promoter polymorphisms and head and neck cancer risk.
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DOI：
10.1371/journal.pone.0062023
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Zheng H
中科院分区：
文献类型：
--
作者：
Zhang C;Li C;Zhu M;Zhang Q;Xie Z;Niu G;Song X;Jin L;Li G;Zheng H
基质金属蛋白酶（MMP） 2、MMP3和MMP9基因的1306 C>T、1171 5A>6A和1562C>T多态性已被发现具有功能性，并可能参与头颈部癌的发生。然而，检查MMP多态性与头颈癌（HNC）风险之间关系的病例对照研究的结果仍然没有定论。因此，我们进行了一项荟萃分析，以进一步评估这些多态性在HNC发展中的作用。我们检索了PubMed、ISI Web of Knowledge、MEDLINE、Embase和谷歌Scholar，以确定meta分析中所有已发表的关于MMP2-1306 C>T、MMP3-1171 5A>6A和MMP9-1562 C>T多态性和HNC风险的病例对照研究。比值比（ORs）和95%置信区间（CIs）用于评估这些多态性与HNC风险之间的关联。本荟萃分析纳入了13项研究。对于MMP2-1306 C>T多态性，在总体比较和基于医院的亚组中，在三种遗传模型下，以及在显性模型下的口腔癌和鼻咽癌中，都观察到显著的相关性。对于MMP3-1171 5A>6A和MMP9-1562 C>T多态性，总体比较未发现关联；然而，在基于种族和肿瘤部位的亚组分析中，在两种遗传对比下，在欧洲人群和咽/喉癌中检测到MMP3-1171 5A>6A多态性与HNC风险之间存在显著关联。这项荟萃分析表明，MMP2-1306 C>T多态性与HNC风险相关，MMP3-1171 5A>6A多态性在某些亚组中也与HNC风险相关。更大样本量的进一步研究是必要的。
The 1306 C>T, 1171 5A>6A, and 1562C>T polymorphisms of matrix metalloproteinase (MMP) 2, MMP3, and MMP9 genes, respectively, have been found to be functional and may contribute to head and neck carcinogenesis. However, the results of case-control studies examining associations between MMP polymorphisms and head and neck cancer (HNC) risk remain inconclusive. Therefore, we performed a meta-analysis to further evaluate the role of these polymorphisms in HNC development. We searched PubMed, ISI Web of Knowledge, MEDLINE, Embase, and Google Scholar to identify all published case-control studies of MMP2-1306 C>T, MMP3-1171 5A>6A, and MMP9-1562 C>T polymorphisms and HNC risk in the meta-analysis. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the association between these polymorphisms and HNC risk. Thirteen studies were included in this meta-analysis. For MMP2-1306 C>T polymorphism, significant associations were observed under three genetic models both in overall comparison and in a hospital-based subgroup, and in oral cavity cancer and nasopharyngeal cancer under dominant model as well. For MMP3-1171 5A>6A and MMP9-1562 C>T polymorphisms, no association was found in overall comparison; however, in subgroup analyses based on ethnicity and tumor site, significant associations were detected between the MMP3-1171 5A>6A polymorphism and HNC risk in a European population and pharyngeal/laryngeal cancer under two genetic contrasts. This meta-analysis suggests that the MMP2-1306 C>T polymorphism is associated with HNC risk, as is the MMP3-1171 5A>6A polymorphism specifically in some subgroups. Further studies with larger sample sizes are warranted.
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影响因子：
4.2
作者：
Bellayr IH;Mu X;Li Y
通讯作者：
Li Y
影响因子：
14.5
作者：
Stetler-Stevenson, WG;Yu, AE
通讯作者：
Yu, AE
影响因子：
3.8
作者：
Vairaktaris, E.;Vassiliou, S.;Patsouris, E.
通讯作者：
Patsouris, E.
DOI：
10.1165/ajrcmb/7.2.120
发表时间：
1992-08-01
影响因子：
6.4
作者：
MURPHY, G;DOCHERTY, AJP
通讯作者：
DOCHERTY, AJP
影响因子：
11.5
作者：
Stokes, Angela;Joutsa, Juho;Kahari, Veli-Matti
通讯作者：
Kahari, Veli-Matti