Similar cortical morphometry trajectories from 5 to 9 years in children with perinatal HIV who started treatment before age 2 years and uninfected controls.
Similar cortical morphometry trajectories from 5 to 9 years in children with perinatal HIV who started treatment before age 2 years and uninfected controls.
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DOI：
10.1186/s12868-023-00783-7
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发表时间：
2023-02-24
期刊：
影响因子：
2.4
通讯作者：
Meintjes, Ernesta M. M.
中科院分区：
文献类型：
--
作者：
Nwosu, Emmanuel C. C.;Holmes, Martha J. J.;Cotton, Mark F. F.;Dobbels, Els;Little, Francesca;Laughton, Barbara;van der Kouwe, Andre;Robertson, Frances;Meintjes, Ernesta M. M.
终生早期抗逆转录病毒治疗（在2岁之前开始）通常有治疗中断期，现在是儿童艾滋病毒感染的标准治疗。尽管横断面研究已经调查了在早期抗逆转录病毒治疗和中断抗逆转录病毒治疗的情况下，与hiv相关的皮质形态差异，但对皮质发育轨迹的长期影响尚不清楚。这项研究比较了来自儿童HIV早期抗逆转录病毒治疗（CHER）试验的围产期感染HIV （CPHIV）的儿童和年龄匹配的未感染HIV的儿童中5至9岁的皮质厚度和折叠（旋转）的纵向轨迹。在FAMCRU （Ubuntu家庭研究中心）随访的75名CHER参与者，以及66名年龄匹配的对照组，在5岁、7岁和/或9岁时接受了3t西门子Allegra的磁共振成像（MRI）。对磁共振图像进行处理，并使用FreeSurfer纵向处理流重建皮质表面。在全脑范围内进行了顶点线性混合效应（LME）分析，以比较CPHIV和对照组之间5至9年间皮质厚度和旋转的平均值和线性变化率，以及检查ART中断的影响。未感染艾滋病毒的儿童在5至9岁时表现出广泛的皮质变薄，其变薄的速度因地区而异，并且区域年龄相关的旋转增加。总体而言，CPHIV中皮质厚度和旋转的方式和发展轨迹相似。然而，在未校正的p < 0.005下，发现有6个区域的CPHIV皮层比未感染的儿童更厚，即双侧岛区、左侧边缘上区、外侧眶额区和颞上区以及右侧内侧额上区。计划中的ART中断不影响皮质形态测定学的发展。虽然我们的研究结果表明，在早期开始抗逆转录病毒治疗的CPHIV患者中，5 - 9岁的皮质形态发育正常，但这些发现需要通过对易感青少年期的纵向随访进一步证实。在线版本包含补充材料，可在10.1186/s12868-023-00783-7获得。
Life-long early ART (started before age 2 years), often with periods of treatment interruption, is now the standard of care in pediatric HIV infection. Although cross-sectional studies have investigated HIV-related differences in cortical morphology in the setting of early ART and ART interruption, the long-term impact on cortical developmental trajectories is unclear. This study compares the longitudinal trajectories of cortical thickness and folding (gyrification) from age 5 to 9 years in a subset of children perinatally infected with HIV (CPHIV) from the Children with HIV Early antiRetroviral therapy (CHER) trial to age-matched children without HIV infection. 75 CHER participants in follow-up care at FAMCRU (Family Centre for Research with Ubuntu), as well as 66 age-matched controls, received magnetic resonance imaging (MRI) on a 3 T Siemens Allegra at ages 5, 7 and/or 9 years. MR images were processed, and cortical surfaces reconstructed using the FreeSurfer longitudinal processing stream. Vertex-wise linear mixed effects (LME) analyses were performed across the whole brain to compare the means and linear rates of change of cortical thickness and gyrification from 5 to 9 years between CPHIV and controls, as well as to examine effects of ART interruption. Children without HIV demonstrated generalized cortical thinning from 5 to 9 years, with the rate of thinning varying by region, as well as regional age-related gyrification increases. Overall, the means and developmental trajectories of cortical thickness and gyrification were similar in CPHIV. However, at an uncorrected p < 0.005, 6 regions were identified where the cortex of CPHIV was thicker than in uninfected children, namely bilateral insula, left supramarginal, lateral orbitofrontal and superior temporal, and right medial superior frontal regions. Planned ART interruption did not affect development of cortical morphometry. Although our results suggest that normal development of cortical morphometry between the ages of 5 and 9 years is preserved in CPHIV who started ART early, these findings require further confirmation with longitudinal follow-up through the vulnerable adolescent period. The online version contains supplementary material available at 10.1186/s12868-023-00783-7.
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DOI：
10.1073/pnas.0402680101
发表时间：
2004-05-25
影响因子：
11.1
作者：
Gogtay, N;Giedd, JN;Thompson, PM
通讯作者：
Thompson, PM
影响因子：
5.7
作者：
Ducharme S;Albaugh MD;Nguyen TV;Hudziak JJ;Mateos-Pérez JM;Labbe A;Evans AC;Karama S;Brain Development Cooperative Group
通讯作者：
Brain Development Cooperative Group
影响因子：
3.8
作者：
Bunupuradah, Torsak;Duong, Trinh;Gibb, Diana
通讯作者：
Gibb, Diana
影响因子：
2.9
作者：
Randall SR;Warton CMR;Holmes MJ;Cotton MF;Laughton B;van der Kouwe AJW;Meintjes EM
通讯作者：
Meintjes EM
DOI：
10.3174/ajnr.a4921
发表时间：
2016-12
期刊：
AJNR. American journal of neuroradiology
影响因子：
--
作者：
Ackermann C;Andronikou S;Saleh MG;Laughton B;Alhamud AA;van der Kouwe A;Kidd M;Cotton MF;Meintjes EM
通讯作者：
Meintjes EM