Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine.
Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine.
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肾脏替代疗法对A（H1N1）PDM09疫苗的影响后对免疫反应的影响。
DOI：
10.1111/irv.12024
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发表时间：
2013-09
影响因子：
4.4
通讯作者：
Campistol JM
中科院分区：
文献类型：
--
作者：
Quintana LF;Serra N;De Molina-Llauradó P;Blasco M;Martinez M;Campos B;Bayas JM;Pumarola T;Campistol JM
请引用这篇论文：Quintana et al.（2012）肾脏替代疗法对一剂和两剂A（H1N1）pdm 09疫苗后免疫应答的影响。流感和其他呼吸道病毒DOI：10.1111/irv.12024。 终末期肾病患者对疫苗接种的反应降低，因为与尿毒症相关的免疫系统受到普遍抑制。 目的我们评估了四个肾脏病患者群体接种一剂和两剂疫苗后对含佐剂的甲型H1N1流感pdm 09疫苗（Pandemrix®）的免疫应答和免疫原性的差异因素。 方法151例患者包括58例慢性血液透析患者、52例肾移植患者、14例腹膜透析患者和27例准备进行肾脏替代治疗的晚期慢性肾脏病患者。 通过使用血凝抑制试验监测A（H1N1）pdm 09滴度来测量流感特异性抗体水平。 结果两剂疫苗接种后42 d的血清阳转率，血液透析组为80%，肾移植组为64.9%，晚期慢性肾脏病组为100%，腹膜透析组为71.4%（P= 0.041）。 结论在四种肾脏疾病中，对两剂甲型H1N1流感疫苗的免疫应答不同，证实了透析前、血液透析和腹膜透析中的血清保护与接种一剂疫苗的一般人群相似。 相比之下，肾移植受者与良好的同种异体移植功能显示保护不足和三联免疫抑制治疗，包括钙调磷酸酶抑制剂，霉酚酸酯和类固醇的负面影响接种后的血清转换肾受体。
Please cite this paper as: Quintana et al. (2012) Influence of renal replacement therapy on immune response after one and two doses of the A(H1N1) pdm09 vaccine. Influenza and Other Respiratory Viruses DOI: 10.1111/irv.12024. Background Patients with end‐stage renal disease have a reduced response to vaccination because of the general suppression of the immune system associated with uraemia. Objectives We evaluated the immune response and differential factors in the immunogenecity to an adjuvanted A(H1N1) pdm09 vaccine (Pandemrix®) in four populations of renal patients after one and two doses of vaccine. Patients Methods 151 patients were included in this study: 58 chronic haemodialysis patients, 52 renal allograft recipients, 14 peritoneal dialysis patients and 27 patients with advanced chronic kidney disease in preparation for kidney replacement therapy. Influenza‐specific antibody levels were measured by monitoring A(H1N1) pdm09 titres using a haemagglutination inhibition assay. Results The seroconversion rate at 42 days after two vaccine doses was 80% in the haemodialysis group, 64·9% in the renal allograft recipients group, 100% in the advanced chronic kidney disease group and 71·4% in the peritoneal dialysis group (P = 0·041). Conclusions Immune response to two doses of the influenza A H1N1 vaccine is dissimilar in the four renal conditions, confirming that seroprotection in pre‐dialysis, haemodialysis and peritoneal dialysis is similar to that in the general population vaccinated with one dose. In contrast, renal transplant recipients with good allograft function showed inadequate protection and triple immunosuppressive therapy including calcineurin inhibitors, mycophenolate and steroids negatively influenced seroconversion after vaccination in renal recipients.
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影响因子：
2.9
作者：
Kausz, Annamaria T.;Gilbertson, David T.
通讯作者：
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影响因子：
6.1
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Agrawal, Sudhanshu;Gollapudi, Pavan;Vaziri, Nosratola D.
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Litjens, Nicolle Helena Renier;Huisman, Martin;Betjes, Michiel Gerardus Henricus
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影响因子：
2.1
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通讯作者：
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