massPix: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics.

massPix: an R package for annotation and interpretation of mass spectrometry imaging data for lipidomics.
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DOI:
10.1007/s11306-017-1252-5
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发表时间:
2017
期刊:
Metabolomics : Official journal of the Metabolomic Society
影响因子:
--
通讯作者:
Hall Z
Hall Z
中科院分区:
其他
文献类型:
--
作者:
Bond NJ;Koulman A;Griffin JL;Hall Z

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质谱成像(MSI)实验产生复杂的多维数据集,这需要专业的数据分析工具。我们开发了massPix-an R软件包,用于分析和解释组织中脂质MSI的数据。 massPix生成单离子图像,执行多变量统计,并根据生成的脂质库的准确质量匹配提供推定的脂质注释。具有高光谱相似性的组织区域的分类可以通过主成分分析(PCA)或k均值聚类来执行。 massPix是一种用于MSI数据分析和统计解释的开源工具,对脂质组学应用特别有用。
Mass spectrometry imaging (MSI) experiments result in complex multi-dimensional datasets, which require specialist data analysis tools. We have developed massPix—an R package for analysing and interpreting data from MSI of lipids in tissue. massPix produces single ion images, performs multivariate statistics and provides putative lipid annotations based on accurate mass matching against generated lipid libraries. Classification of tissue regions with high spectral similarly can be carried out by principal components analysis (PCA) or k-means clustering. massPix is an open-source tool for the analysis and statistical interpretation of MSI data, and is particularly useful for lipidomics applications.
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