Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila.

Sensorimotor transformation underlying odor-modulated locomotion in walking Drosophila.
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果蝇行走中的气味调节运动的基础感官转化。

DOI:
10.1038/s41467-023-42613-8
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发表时间:
2023-10-26
影响因子:
16.6
通讯作者:
Bhandawat, Vikas
Bhandawat, Vikas
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Tao, Liangyu;Wechsler, Samuel P.;Bhandawat, Vikas

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大多数现实世界的行为--比如气味引导的运动--都是在不完全信息的情况下进行的。嗅觉受体神经元(ORN)类的活动提供有关气味身份的信息,但不是其来源的位置。在这项研究中,我们调查的感觉运动的转换,ORN激活运动的变化,在果蝇通过光遗传学激活不同组合的ORN类和测量运动的变化。三个特征描述了这种感觉运动转变:首先,运动取决于瞬时放电频率(f)及其变化(df);两者共同充当短期记忆,使苍蝇能够自动调整其运动程序以适应感觉环境。第二,(f,df)和运动参数,如速度或曲率之间的映射是不同的激活ORN的每种模式。最后,气味暴露后,感觉运动映射随着时间的推移而变化,允许在更长的时间尺度上进行信息整合。动物通过改变它们的运动来响应发出资源信号的气味,从而找到并靠近资源。在这里,作者使用果蝇对气味的运动反应,确定了一个简单的策略,使其运动程序自动适应感官环境。
Most real-world behaviors – such as odor-guided locomotion - are performed with incomplete information. Activity in olfactory receptor neuron (ORN) classes provides information about odor identity but not the location of its source. In this study, we investigate the sensorimotor transformation that relates ORN activation to locomotion changes in Drosophila by optogenetically activating different combinations of ORN classes and measuring the resulting changes in locomotion. Three features describe this sensorimotor transformation: First, locomotion depends on both the instantaneous firing frequency (f) and its change (df); the two together serve as a short-term memory that allows the fly to adapt its motor program to sensory context automatically. Second, the mapping between (f, df) and locomotor parameters such as speed or curvature is distinct for each pattern of activated ORNs. Finally, the sensorimotor mapping changes with time after odor exposure, allowing information integration over a longer timescale. Animals find and stay close to resources by altering their locomotion in response to odors that signal resources. Here the authors identify, using Drosophila locomotion in response to odor, a simple strategy that adapts its motor program to sensory context automatically.
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