Progression from being at-risk to psychosis: next steps.
Progression from being at-risk to psychosis: next steps.
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DOI：
10.1038/s41537-020-00117-0
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发表时间：
2020-10-05
影响因子：
5.4
通讯作者：
Metzak P
中科院分区：
文献类型：
--
作者：
Addington J;Farris M;Devoe D;Metzak P
在过去的20年里，人们对那些被认为有患精神病风险的人进行了大量的研究。已经学到了很多东西，研究结果令人鼓舞。本文的目的是提供精神病风险研究的最新现状，以及下一步可能是在检查从癫痫到精神病的进展。在准确预测方面取得了进展，但在确定、诊断、使用数据驱动的选择方法以及缺乏外部验证方面存在一些方法学问题。虽然已经有几个高质量的治疗试验，这种临床高风险人群的异质性必须得到解决，使他们的治疗需求可以得到适当的满足。对未来的建议包括更多的合作研究方案，并确保它们在标准和成果方面是可获得的和统一的，以便该领域能够继续向前发展，发展大型合作财团，并增加对多地点项目的供资。
Over the past 20 years there has been a great deal of research into those considered to be at risk for developing psychosis. Much has been learned and studies have been encouraging. The aim of this paper is to offer an update of the current status of research on risk for psychosis, and what the next steps might be in examining the progression from CHR to psychosis. Advances have been made in accurate prediction, yet there are some methodological issues in ascertainment, diagnosis, the use of data-driven selection methods and lack of external validation. Although there have been several high-quality treatment trials the heterogeneity of this clinical high-risk population has to be addressed so that their treatment needs can be properly met. Recommendations for the future include more collaborative research programmes, and ensuring they are accessible and harmonized with respect to criteria and outcomes so that the field can continue to move forward with the development of large collaborative consortiums as well as increased funding for multisite projects.
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影响因子：
4.5
作者：
Addington J;Cadenhead KS;Cornblatt BA;Mathalon DH;McGlashan TH;Perkins DO;Seidman LJ;Tsuang MT;Walker EF;Woods SW;Addington JA;Cannon TD
通讯作者：
Cannon TD
影响因子：
--
作者：
Amminger, G. Paul;Schafer, Miriam R.;Berger, Gregor E.
通讯作者：
Berger, Gregor E.
影响因子：
--
作者：
Addington, Jean;Devoe, Daniel J;Santesteban-Echarri, Olga
通讯作者：
Santesteban-Echarri, Olga
DOI：
10.1016/j.nicl.2017.03.001
发表时间：
2017
期刊：
NeuroImage. Clinical
影响因子：
--
作者：
Bernard JA;Orr JM;Mittal VA
通讯作者：
Mittal VA
影响因子：
6.6
作者：
Carrion, Ricardo E.;Auther, Andrea M.;Cornblatt, Barbara A.
通讯作者：
Cornblatt, Barbara A.