Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line.
Piceatannol and its metabolite, isorhapontigenin, induce SIRT1 expression in THP-1 human monocytic cell line.
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作者：
Kawakami S;Kinoshita Y;Maruki-Uchida H;Yanae K;Sai M;Ito T
皮杉醇是一种植物化学物质，大量存在于百香果（Passiflora edulis）种子中，是白藜芦醇的类似物。近年来，研究了大鼠对皮杉醇的吸收和代谢，在大鼠血浆中检测到皮杉醇代谢物异橙皮素o -甲基皮杉醇。为了阐明picetanol及其代谢物的功能，我们研究了picetanol及其代谢物处理THP-1单核细胞后sirtuin 1 （SIRT1）的表达，并与白藜芦醇及其代谢物的作用进行了比较。皮杉醇和白藜芦醇上调SIRT1 mRNA和SIRT1蛋白的表达水平。含有高水平皮杉醇的百香果种子提取物也上调了SIRT1 mRNA的表达。代谢产物中，异橙皮素上调SIRT1 mRNA表达，而白藜芦醇葡萄糖醛酸酯和硫酸盐对SIRT1表达无影响。这些发现表明，摄入皮杉醇后，不仅皮杉醇本身，其代谢物异橙皮素也参与了SIRT1表达的上调。
Piceatannol is a phytochemical that is present in large amounts in passion fruit (Passiflora edulis) seeds, and is an analog of resveratrol. Recently, the absorption and metabolism of piceatannol were investigated in rats, and isorhapontigenin, O-methyl piceatannol, was detected as a piceatannol metabolite in rat plasma. To elucidate the function of piceatannol and its metabolites, we investigated the expression of sirtuin 1 (SIRT1) in THP-1 monocytic cells after treatment with piceatannol and its metabolites, and compared their effects with those of resveratrol and its metabolites. Piceatannol and resveratrol upregulated the expression levels of SIRT1 mRNA and SIRT1 protein. An extract of passion fruit seeds, which contained high levels of piceatannol, also upregulated SIRT1 mRNA expression. As for the metabolites, isorhapontigenin upregulated SIRT1 mRNA expression, whereas resveratrol glucuronides and sulfate did not affect SIRT1 expression. These findings indicate that after intake of piceatannol, not only piceatannol itself, but also its metabolite, isorhapontigenin, contributed to the upregulation of SIRT1 expression.
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影响因子：
2
作者：
Maruki-Uchida, Hiroko;Kurita, Ikuko;Ito, Tatsuhiko
通讯作者：
Ito, Tatsuhiko
影响因子：
7.3
作者：
Hoshino J;Park EJ;Kondratyuk TP;Marler L;Pezzuto JM;van Breemen RB;Mo S;Li Y;Cushman M
通讯作者：
Cushman M
DOI：
10.1016/j.bbapap.2009.10.025
发表时间：
2010-08
期刊：
Biochimica et biophysica acta
影响因子：
--
作者：
Baur JA
通讯作者：
Baur JA
影响因子：
3.7
作者：
Eseberri I;Lasa A;Churruca I;Portillo MP
通讯作者：
Portillo MP
DOI：
10.1016/j.bbrc.2012.09.042
发表时间：
2012-10-12
影响因子：
3.1
作者：
Takeda-Watanabe, Ai;Kitada, Munehiro;Koya, Daisuke
通讯作者：
Koya, Daisuke