Telomeres and telomere dynamics: relevance to cancers of the GI tract.
Telomeres and telomere dynamics: relevance to cancers of the GI tract.
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DOI：
10.1586/17474124.2013.848790
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发表时间：
2013-11
影响因子：
3.9
通讯作者：
Boardman LA
中科院分区：
文献类型：
--
作者：
Basu N;Skinner HG;Litzelman K;Vanderboom R;Baichoo E;Boardman LA
Aberrations in telomere length and telomere maintenance contribute to cancer development. In this article, we review basic principles of telomere length in normal and tumor tissue and the presence of the two main telomere maintenance pathways as they pertain to GI tract cancer. Peripheral blood telomeres are shorter in patients with many types of GI tract cancers. Telomere length in tumor DNA also appears to shorten early in cancer development. Tumor telomere shortening is often accompanied by telomerase activation to protect genetically damaged DNA from normal cell senescence or apoptosis, allowing immortalized but damaged DNA to persist. Alternative lengthening of telomeres (ALT) is another mechanism used by cancer to maintain telomere length in cancer cells. Telomerase and ALT activators and inhibitors may become important chemopreventive or chemotherapeutic agents as our understanding of telomere biology, specific telomere related phenotypes, and its relationship to carcinogenesis increases.
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