Clostridium Butyricum ZJU-F1 Benefits the Intestinal Barrier Function and Immune Response Associated with Its Modulation of Gut Microbiota in Weaned Piglets.
Clostridium Butyricum ZJU-F1 Benefits the Intestinal Barrier Function and Immune Response Associated with Its Modulation of Gut Microbiota in Weaned Piglets.
复制标题
丁酸梭菌 ZJU-F1 有益于断奶仔猪肠道屏障功能和与其调节肠道微生物群相关的免疫反应
作者：
Fu J;Wang T;Xiao X;Cheng Y;Wang F;Jin M;Wang Y;Zong X
本研究探讨日粮中丁酸梭菌ZJU-F1对断奶仔猪营养物质表观消化率、肠道屏障功能、免疫反应及微生物区系的影响，旨在为丁酸梭菌替代抗生素在断奶仔猪中的应用提供理论依据。将120头断奶仔猪随机分为4个处理组，分别饲喂添加抗生素（CON）、地衣芽孢杆菌（BL）、丁酸梭菌ZJU-F1（CB）或丁酸梭菌和地衣芽孢杆菌（CB-BL）的基础日粮。结果表明，CB和CB-BL处理增加了肠道对营养物质的消化率，降低了肠道通透性，增加了肠道紧密连接蛋白和粘蛋白的表达，从而维持了肠上皮屏障的完整性。 CB和CB-BL作为外源益生菌，还被发现可以刺激断奶仔猪的免疫反应，提高回肠中抗菌肽的表达。此外，膳食CB和CB-BL增加了乳酸菌的比例。饲喂CB和CB-BL的仔猪盲肠中丁酸、丙酸、乙酸和总酸的水平显着增加。此外，我们在体外验证了丁酸梭菌ZJU-F1对肠道屏障功能和免疫反应的影响，发现丁酸梭菌ZJU-F1改善了肠道功能并增强了TLR-2-MyD88-NF-κB信号传导。
This study investigated the effects of dietary C. butyricum ZJU-F1 on the apparent digestibility of nutrients, intestinal barrier function, immune response, and microflora of weaned piglets, with the aim of providing a theoretical basis for the application of Clostridium butyricum as an alternative to antibiotics in weaned piglets. A total of 120 weanling piglets were randomly divided into four treatment groups, in which piglets were fed a basal diet supplemented with antibiotics (CON), Bacillus licheniformis (BL), Clostridium butyricum ZJU-F1 (CB), or Clostridium butyricum and Bacillus licheniformis (CB-BL), respectively. The results showed that CB and CB-BL treatment increased the intestinal digestibility of nutrients, decreased intestinal permeability, and increased intestinal tight junction protein and mucin expression, thus maintaining the integrity of the intestinal epithelial barrier. CB and CB-BL, as exogenous probiotics, were also found to stimulate the immune response of weaned piglets and improve the expression of antimicrobial peptides in the ileum. In addition, dietary CB and CB-BL increased the proportion of Lactobacillus. The levels of butyric acid, propionic acid, acetic acid, and total acid were significantly increased in the ceca of piglets fed CB and CB-BL. Furthermore, we validated the effects of C. butyricum ZJU-F1 on the intestinal barrier function and immune response in vitro and found C. butyricum ZJU-F1 improved intestinal function and enhanced the TLR-2-MyD88-NF-κB signaling.
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影响因子：
24.5
作者：
Kruis, W;Fric, P;Schulze, J
通讯作者：
Schulze, J
DOI：
10.1016/j.ijfoodmicro.2006.09.018
发表时间：
2007-03-20
影响因子：
5.4
作者：
Geier, Mark S.;Butler, Ross N.;Howarth, Gordon S.
通讯作者：
Howarth, Gordon S.
猴头菇多糖通过调节氧化应激、炎症相关信号通路和调节肠道微生物群的组成来减轻 C57BL/6 小鼠的结肠炎
影响因子：
5.6
作者：
Ren, Yilin;Geng, Yan;Xu, Zheng-Hong
通讯作者：
Xu, Zheng-Hong
影响因子：
3.9
作者：
Bleavins, Katherine;Perone, Patricia;Naik, Madhav;Rehman, Muneeb;Aslam, Muhammad N.;Dame, Michael K.;Meshinchi, Sasha;Bhagavathula, Narasimharao;Varani, James
通讯作者：
Varani, James
影响因子：
3.6
作者：
Henker, Jobst;Laass, Martin W.;Schulze, Juergen
通讯作者：
Schulze, Juergen