Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behavior problems in children.
Sibling-based association analyses of the serotonin transporter polymorphism and internalizing behavior problems in children.
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基于兄弟姐妹的儿童血清素转运蛋白多态性和内化行为问题的关联分析。
DOI：
10.1111/1469-7610.00180
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Hewitt,JohnK
中科院分区：
文献类型：
--
作者：
Young,SusanE;Smolen,Andrew;Stallings,MichaelC;Corley,RobinP;Hewitt,JohnK
背景：儿童期的内化问题往往是发展为更严重的精神综合征的前兆，包括焦虑和抑郁障碍。对这些疾病病因学的双胞胎研究表明，焦虑和抑郁背后的遗传风险因素是高度相关的。然而，造成这种风险的具体遗传机制尚未确定。方法：我们对711名儿童进行了一项关于行为和情感发展的纵向双胞胎研究，研究了儿童内化问题与血清素转运基因（5‐HTTLPR）功能多态性之间的关系。在4岁、7岁、9岁、10岁、11岁和12岁时使用儿童行为检查表（CBCL）父母报告表测量内化问题。在控制种群分层的同时，我们采用了基于兄弟姐妹的方法来估计等位基因与数量性状的关联。结果：在任何年龄的CBCL内化问题，包括躯体抱怨、退缩和焦虑/抑郁的分量表，均未发现关联。结论：因此，尽管我们的结果不支持5‐HTTLPR有助于内化行为问题的维度表达的假设，但这并不排除它是一种有趣的多态性的可能性，可以在寻找与重度抑郁症和/或焦虑症相关的遗传风险因素中进行研究。
Background:Childhood internalizing problems are often precursors in the development of more serious psychiatric syndromes including anxiety and depressive disorders. Twin studies of the etiology of these disorders suggest that the genetic risk factors underlying anxiety and depression are highly correlated. However, the specific genetic mechanisms responsible for this risk have not yet been identified.Methods:We examined the association between childhood internalizing problems and a functional polymorphism in the serotonin transporter gene (5‐HTTLPR) in 711 children participating in a longitudinal twin study of behavioral and emotional development. Internalizing problems were measured at ages 4, 7, 9, 10, 11 and 12 years using the Child Behavior Checklist (CBCL) parent report form. We applied a sibling‐based methodology for estimating allelic association with quantitative traits, while controlling for population stratification.Results:No associations were found for CBCL Internalizing problems at any age, including the subscales for Somatic Complaints, Withdrawn and Anxiety/Depression.Conclusions:Thus, although our results did not support the hypothesis that the 5‐HTTLPR contributes to a dimensional expression of internalizing behavior problems, this does not rule out the possibility that it is an interesting polymorphism to pursue in the search for genetic risk factors related to major depressive and/or anxiety disorders.
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