Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma.
Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma.
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重新编程全身和局部免疫功能以增强针对胶质母细胞瘤的免疫治疗
DOI：
10.1038/s41467-023-35957-8
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发表时间：
2023-01-26
影响因子：
16.6
通讯作者：
Chen, Jun
中科院分区：
文献类型：
--
作者：
Zhou, Songlei;Huang, Yukun;Chen, Yu;Liu, Yipu;Xie, Laozhi;You, Yang;Tong, Shiqiang;Xu, Jianpei;Jiang, Gan;Song, Qingxiang;Mei, Ni;Ma, Fenfen;Gao, Xiaoling;Chen, Hongzhuan;Chen, Jun
The limited benefits of immunotherapy against glioblastoma (GBM) is closely related to the paucity of T cells in brain tumor bed. Both systemic and local immunosuppression contribute to the deficiency of tumor-infiltrating T cells. However, the current studies focus heavily on the local immunosuppressive tumor microenvironment but not on the co-existence of systemic immunosuppression. Here, we develop a nanostructure named Nano-reshaper to co-encapsulate lymphopenia alleviating agent cannabidiol and lymphocyte recruiting cytokine LIGHT. The results show that Nano-reshaper increases the number of systemic T cells and improves local T-cell recruitment condition, thus greatly increasing T-cell infiltration. When combined with immune checkpoint inhibitor, this therapeutic modality achieves 83.3% long-term survivors without recurrence in GBM models in male mice. Collectively, this work unveils that simultaneous reprogramming of systemic and local immune function is critical for T-cell based immunotherapy and provides a clinically translatable option for combating brain tumors.
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影响因子：
17.1
作者：
Allen E;Jabouille A;Rivera LB;Lodewijckx I;Missiaen R;Steri V;Feyen K;Tawney J;Hanahan D;Michael IP;Bergers G
通讯作者：
Bergers G
影响因子：
4.7
作者：
Himes BT;Geiger PA;Ayasoufi K;Bhargav AG;Brown DA;Parney IF
通讯作者：
Parney IF
影响因子：
17.1
作者：
Goodwin TJ;Zhou Y;Musetti SN;Liu R;Huang L
通讯作者：
Huang L
影响因子：
82.9
作者：
Binnewies M;Roberts EW;Kersten K;Chan V;Fearon DF;Merad M;Coussens LM;Gabrilovich DI;Ostrand-Rosenberg S;Hedrick CC;Vonderheide RH;Pittet MJ;Jain RK;Zou W;Howcroft TK;Woodhouse EC;Weinberg RA;Krummel MF
通讯作者：
Krummel MF
影响因子：
11.2
作者：
Fecci, PE;Mitchell, DA;Sampson, JH
通讯作者：
Sampson, JH