Vagus nerve controls resolution and pro-resolving mediators of inflammation.
Vagus nerve controls resolution and pro-resolving mediators of inflammation.
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DOI：
10.1084/jem.20132103
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发表时间：
2014-06-02
期刊：
影响因子：
--
通讯作者：
Serhan CN
中科院分区：
文献类型：
--
作者：
Mirakaj V;Dalli J;Granja T;Rosenberger P;Serhan CN
轴突引导分子 netrin-1 促进炎症消退，netrin-1 和 resolvin D1 相互诱导彼此表达。炎症的消退现在被认为是涉及促消退介质的生物合成活性过程。在这里，我们发现，在酵母聚糖引发的腹膜炎症中，迷走神经调节 Netrin-1（一种激活消退的轴突引导分子）的局部表达，并且迷走神经切断术减少了局部促消退介质，从而延迟了消退。在 netrin-1+/- 小鼠中，与 Ntn1+/+ 相比，resolvin D1 (RvD1) 在减少中性粒细胞流入促进腹膜炎消退方面效果较差。 Netrin-1 缩短了消退间隔，减少了中性粒细胞渗出，减少了促炎介质，并刺激消退素、保护素和脂氧素的产生。与 netrin-1 一起孵育的人单核细胞产生促溶解介质，包括溶解素和脂氧素。 Netrin-1 和 RvD1 表现出双向激活，它们刺激彼此的表达并增强胞吞作用。这些结果表明迷走神经调节 netrin-1 和促解析脂质介质，它们以双向方式发挥作用以刺激解析，并为局部神经元控制解析的新机制提供了证据。
Axonal guidance molecule netrin-1 promotes resolution of inflammation, with netrin-1 and resolvin D1 mutually inducing each other’s expression. Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal guidance molecule that activates resolution, and that vagotomy reduced local pro-resolving mediators, thereby delaying resolution. In netrin-1+/− mice, resolvin D1 (RvD1) was less effective in reducing neutrophil influx promoting resolution of peritonitis compared with Ntn1+/+. Netrin-1 shortened the resolution interval, decreasing exudate neutrophils, reducing proinflammatory mediators, and stimulating the production of resolvins, protectins, and lipoxins. Human monocytes incubated with netrin-1 produced proresolving mediators, including resolvins and lipoxins. Netrin-1 and RvD1 displayed bidirectional activation in that they stimulated each other’s expression and enhanced efferocytosis. These results indicate that the vagus nerve regulates both netrin-1 and pro-resolving lipid mediators, which act in a bidirectional fashion to stimulate resolution, and provide evidence for a novel mechanism for local neuronal control of resolution.
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影响因子：
62.1
作者：
Serhan, Charles N.;Petasis, Nicos A.
通讯作者：
Petasis, Nicos A.
DOI：
10.1161/atvbaha.112.249508
发表时间：
2012-08
期刊：
Arteriosclerosis, thrombosis, and vascular biology
影响因子：
--
作者：
Norling LV;Dalli J;Flower RJ;Serhan CN;Perretti M
通讯作者：
Perretti M
DOI：
10.1126/science.1230720
发表时间：
2013-01-11
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Tabas I;Glass CK
通讯作者：
Glass CK
影响因子：
4.4
作者：
Bannenberg, GL;Chiang, N;Serhan, CN
通讯作者：
Serhan, CN
影响因子：
4.8
作者：
Merched, Aksam J.;Ko, Kerry;Chan, Lawrence
通讯作者：
Chan, Lawrence