Oxidative stress: Biomarkers and novel therapeutic pathways.
Oxidative stress: Biomarkers and novel therapeutic pathways.
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DOI：
10.1016/j.exger.2010.01.004
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发表时间：
2010-03
影响因子：
3.9
通讯作者：
Shang, Yan Chen
中科院分区：
文献类型：
--
作者：
Maiese, Kenneth;Chong, Zhao Zhong;Hou, Jinling;Shang, Yan Chen
关键词：
氧化应激显著影响多种细胞途径，可导致全身各种疾病的开始和进展。因此，阐明抗氧化应激的新治疗策略的组分和功能以进一步临床诊断和护理变得势在必行。特别是，生长因子和细胞因子促红细胞生成素（EPO）和O类（FoxO）的哺乳动物叉头转录因子的成员可能提供新的治疗方案的最大希望，因为这些药物和它们监督的细胞途径涵盖了一系列直接影响祖细胞发育，细胞存活和退化，代谢，免疫功能和癌细胞侵袭的关键功能。此外，EPO和FoxOs不仅作为治疗靶点，而且作为疾病发作和进展的生物标志物，因为它们的细胞途径与几种独特的信号转导途径密切相关并重叠。然而，EPO和FoxO的生物学结果有时可能是意想不到的和不期望的，这可能会引起对这些药物的警惕，并需要进一步的研究。在这里，我们提出了令人兴奋的，以及复杂的作用EPO和FoxOs拥有揭示的好处，以及这些药物的细胞生物学和临床护理的过程中，从干细胞发育到不受控制的细胞增殖的风险。
Oxidative stress significantly impacts multiple cellular pathways that can lead to the initiation and progression of varied disorders throughout the body. It therefore becomes imperative to elucidate the components and function of novel therapeutic strategies against oxidative stress to further clinical diagnosis and care. In particular, both the growth factor and cytokine erythropoietin (EPO) and members of the mammalian forkhead transcription factors of the O class (FoxOs) may offer the greatest promise for new treatment regimens since these agents and the cellular pathways they oversee cover a range of critical functions that directly influence progenitor cell development, cell survival and degeneration, metabolism, immune function, and cancer cell invasion. Furthermore, both EPO and FoxOs function not only as therapeutic targets, but also as biomarkers of disease onset and progression, since their cellular pathways are closely linked and overlap with several unique signal transduction pathways. However, biological outcome with EPO and FoxOs may sometimes be both unexpected and undesirable that can raise caution for these agents and warrant further investigations. Here we present the exciting as well as complicated role EPO and FoxOs possess to uncover the benefits as well as the risks of these agents for cell biology and clinical care in processes that range from stem cell development to uncontrolled cellular proliferation.
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影响因子：
3.1
作者：
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通讯作者：
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影响因子：
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作者：
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作者：
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