Skin Vascular Resistance Decreases during 5-HT-Induced Hypotension in the Rat.
Skin Vascular Resistance Decreases during 5-HT-Induced Hypotension in the Rat.
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DOI：
10.3390/biomedicines11020547
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发表时间：
2023-02-13
期刊：
影响因子：
4.7
通讯作者：
中科院分区：
文献类型：
--
作者：
作为公认的血管扩张剂，5-羟色胺（5-HT， 5-羟色胺）的输注通过降低大鼠的总外周阻力来降低血压。目前尚不清楚是哪些血管床/组织导致了这种下降。我们假设皮肤内血流量的增加，通过温度调节尾巴和爪子的温度升高(T)来测量，至少部分通过主动血管舒张使5- ht诱导的血压降低。用Optris PI640热像仪测量麻醉雄性大鼠皮肤温度调节区域的温度。以25mg /min的速度向股静脉注射5-HT，分别在注射前、注射中、注射后记录动物的血压、脚爪及尾部4个部位（TL1-4）的体温。与我们的假设相反，在5-HT注入前和过程中，爪子和尾巴的温度是稳定的，在15分钟的恢复期实际上是升高的。这一发现表明，注射5-HT后观察到的血压下降并不是皮肤循环充血所必需的，但皮肤血管阻力的降低在总外周阻力的下降中起作用。
A recognized vasodilator, the infusion of 5-hydroxytryptamine (5-HT, serotonin) decreases blood pressure through the reduction of total peripheral resistance in the rat. It is not clear which vascular beds/tissues are responsible for this fall. We hypothesized that an increase in blood flow within the skin, measured as an elevated temperature (T) in the thermoregulatory tail and paws, enables at least part of 5-HT-induced reduction in blood pressure through active vasodilation. The temperature of thermoregulatory regions of the skin of an anesthetized male, Sprague Dawley rats were measured using a Optris PI640 thermal camera. The blood pressure of the animal and the temperature of each paw and four locations along the tail (TL1-4) were recorded before, during, and after the infusion of 5-HT at a rate of 25 mg/min into a femoral vein. Contrary to our hypothesis, the temperature of the paws and tail was stable before and during 5-HT infusion and actually increased during the 15-min recovery period. This finding suggests that hyperemia of the skin circulation is not necessary for the fall in blood pressure observed with infused 5-HT, but that a reduction in cutaneous vascular resistance plays a part in the fall in total peripheral resistance.
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影响因子：
2.7
作者：
Seitz BM;Fink GD;Watts SW
通讯作者：
Watts SW
DOI：
10.1016/0024-3205(67)90155-5
发表时间：
1967-01-01
期刊：
LIFE SIC
影响因子：
--
作者：
CARLSON, L. A.;EKELUND, L. G.;ORO, L.
通讯作者：
ORO, L.
影响因子：
3.6
作者：
De Vries, P;De Visser, PA;Saxena, PR
通讯作者：
Saxena, PR
影响因子：
3.1
作者：
DING, XR;STIER, CT;ITSKOVITZ, HD
通讯作者：
ITSKOVITZ, HD
影响因子：
5.5
作者：
Voronova IP
通讯作者：
Voronova IP