Signal transduction in vasculogenesis and developmental angiogenesis.
Signal transduction in vasculogenesis and developmental angiogenesis.
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DOI：
10.1387/ijdb.103213sp
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
D'Amore PA
中科院分区：
文献类型：
--
作者：
Patel-Hett S;D'Amore PA
脉管系统是一种高度专门化的器官，其在许多关键生理任务中起作用，包括将氧气和营养物质输送到组织。血管系统的形成是发育中的一个重要和限速步骤，主要通过两种主要机制发生，即血管发生和血管生成。血管发生（血管的从头形成）和血管生成（通过出芽从预先存在的血管生长出新血管）都是复杂的过程，其通过多种细胞类型的精确协调来介导以形成和重塑血管系统。许多信号分子及其与特定受体的相互作用是激活和调节血管形成的关键。这篇综述文章总结了目前的研究现状，涉及已被证明在调节血管发生和血管生成的信号分子，以及已知的分子在血管成熟，缺氧驱动的血管生成和动静脉规格发挥作用。
The vasculature is a highly specialized organ that functions in a number of key physiological tasks including the transport of oxygen and nutrients to tissues. Formation of the vascular system is an essential and rate-limiting step in development and occurs primarily through two main mechanisms, vasculogenesis and angiogenesis. Both vasculogenesis, the de novo formation of vessels, and angiogenesis, the growth of new vessels from pre-existing vessels by sprouting, are complex processes that are mediated by the precise coordination of multiple cell types to form and remodel the vascular system. A host of signaling molecules and their interaction with specific receptors are central to activating and modulating vessel formation. This review article summarizes the current state of research involving signaling molecules that have been demonstrated to function in the regulation of vasculogenesis and angiogenesis, as well as molecules known to play a role in vessel maturation, hypoxia-driven angiogenesis and arterial-venous specification.
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影响因子：
56.9
作者：
Asahara, T;Murohara, T;Isner, JM
通讯作者：
Isner, JM
影响因子：
16.2
作者：
Chen, H;Bagri, A;Tessier-Lavigne, M
通讯作者：
Tessier-Lavigne, M
DOI：
10.1073/pnas.95.24.14389
发表时间：
1998-11-24
影响因子：
11.1
作者：
Cao, YH;Linden, P;Alitalo, K
通讯作者：
Alitalo, K
影响因子：
82.9
作者：
Carmeliet, P;Moons, L;Persico, MG
通讯作者：
Persico, MG
影响因子：
64.5
作者：
Benedito, Rui;Roca, Cristina;Adams, Ralf H.
通讯作者：
Adams, Ralf H.