Gastrointestinal regulatory peptides: an overview.

Gastrointestinal regulatory peptides: an overview.
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胃肠调节肽:概述。

DOI:
10.1097/med.0b013e32801233e7
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发表时间:
2007
期刊:
Current opinion in endocrinology, diabetes, and obesity
影响因子:
--
通讯作者:
Wolfe,MMichael
Wolfe,MMichael
中科院分区:
--
文献类型:
--
作者:
Wolfe,MMichael

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调节肽是一种化学信使,它为通常位于不同器官系统中的两个细胞之间提供了一种通信手段。这些多肽通过共享的水环境相互作用;而对于经典的激素和胃肠道多肽来说,这种环境本质上是内分泌的,后者也包括那些通过旁分泌、神经分泌和自分泌途径与其目标更直接沟通的多肽。胃肠调节多肽领域还处于起步阶段,未来几十年将见证这些多肽及其类似物和拮抗剂的发展,作为治疗肥胖和其他营养相关疾病以及其他疾病的潜在新形式。
Regulatory peptides are chemical messengers that provide a means of communication between two cells which are commonly located in different organ systems. The peptides interact via a shared aqueous environment; whereas this environment is endocrine in nature for classic hormones and gastrointestinal peptides, the latter also include those peptides that communicate more directly with their target via paracrine, neurocrine, and autocrine routes. The field of gastrointestinal regulatory peptides is in its infancy, and the coming decades will witness the development of these peptides, as well as analogues and antagonists, as potential new forms of therapy of obesity and other nutrition-related disorders, as well as other maladies.
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DOI: --
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