The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue.
The effects of exercise training on obesity-induced dysregulated expression of adipokines in white adipose tissue.
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DOI：
10.1155/2013/801743
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发表时间：
2013
影响因子：
2.8
通讯作者：
Ohno H
中科院分区：
文献类型：
--
作者：
Sakurai T;Ogasawara J;Kizaki T;Sato S;Ishibashi Y;Takahashi M;Kobayashi O;Oh-Ishi S;Nagasawa J;Takahashi K;Ishida H;Izawa T;Ohno H
肥胖被认为是与生活方式有关的疾病的危险因素，如2型糖尿病和心血管疾病。白色脂肪组织（WAT）不仅是能量的静态储存部位;它还是活跃参与代谢反应并产生体液因子的动态组织，如瘦素和脂联素，它们统称为脂肪因子。此外，由于有大量证据表明，肥胖诱导的WAT中的炎症变化（由包括肿瘤坏死因子-α和单核细胞趋化蛋白1的炎症相关脂肪因子的表达失调引起）有助于胰岛素抵抗的发展，WAT作为导致糖尿病和其他生活方式相关疾病的器官引起了特别的关注。运动训练（TR）不仅导致WAT质量减少，而且还减弱了肥胖诱导的WAT中炎症相关脂肪因子表达失调。因此，TR被广泛用作预防和改善生活方式相关疾病的工具。本文综述了TR对WAT中脂肪因子表达和分泌反应的影响。
Obesity is recognized as a risk factor for lifestyle-related diseases such as type 2 diabetes and cardiovascular disease. White adipose tissue (WAT) is not only a static storage site for energy; it is also a dynamic tissue that is actively involved in metabolic reactions and produces humoral factors, such as leptin and adiponectin, which are collectively referred to as adipokines. Additionally, because there is much evidence that obesity-induced inflammatory changes in WAT, which is caused by dysregulated expression of inflammation-related adipokines involving tumor necrosis factor-α and monocyte chemoattractant protein 1, contribute to the development of insulin resistance, WAT has attracted special attention as an organ that causes diabetes and other lifestyle-related diseases. Exercise training (TR) not only leads to a decrease in WAT mass but also attenuates obesity-induced dysregulated expression of the inflammation-related adipokines in WAT. Therefore, TR is widely used as a tool for preventing and improving lifestyle-related diseases. This review outlines the impact of TR on the expression and secretory response of adipokines in WAT.
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作者：
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通讯作者：
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DOI：
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DOI：
10.1152/ajpendo.2001.281.6.e1340
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2001-12-01
影响因子：
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