Combinations of CYP2A6*4 and Glutathione S-Transferases Gene Polymorphisms Modify the Association Between Maternal Secondhand Smoke Exposure During Pregnancy and Small-for-Gestational-Age.
Combinations of CYP2A6*4 and Glutathione S-Transferases Gene Polymorphisms Modify the Association Between Maternal Secondhand Smoke Exposure During Pregnancy and Small-for-Gestational-Age.
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CYP2A6*4 和谷胱甘肽 S 转移酶基因多态性的组合改变了母亲在怀孕期间接触二手烟和小于胎龄之间的关联。
DOI：
10.1093/ntr/ntv072
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发表时间：
2015-12
期刊：
影响因子：
--
通讯作者：
Chen, Weiqing
中科院分区：
文献类型：
--
作者：
Yuan, Shixin;Guo, Xiaoling;Jia, Deqin;Chen, Weiqing
介绍
在怀孕期间暴露于二手烟（SHS）的妇女中，小于胎龄儿（SGA）出生的风险差异很大。我们研究了这种变化是否可以用母亲的一个I期（CYP 2A 6 *4，烟草毒素的激活）和两个II期（GSTM 1和GSTT 1，解毒）代谢基因型来解释。
方法
我们招募了468名中国孕妇（115名分娩SGA，353名分娩非SGA新生儿）。妊娠期间SHS暴露定义为自我报告的每日暴露时间超过0分钟。我们拟合了多变量逻辑回归模型，以检查CYP 2A 6 *4、GSTM 1和GSTT 1基因多态性及其组合是否改变了SHS暴露与SGA之间的关联。
结果
在总样本中，SGA新生儿的母亲在怀孕期间暴露于SHS的比例高于非SGA新生儿的母亲（38.3%对31.4%）。CYP 2A 6 *4、GSTM 1和GSTT 1基因单独不能改变SHS暴露与SGA之间的关联。CYP 2A 6 *4和GSTT 1高风险基因型的组合（CYP 2A 6 *1/*1和GSTT 1缺失[高风险]与其他组合作为一个整体[低风险]）显著（P值，0.045）改变了SHS暴露与SGA之间的关联。在高危基因型母亲中，妊娠期SHS与SGA显著相关（混杂因素校正比值比，2.31 [95%置信区间，1.20-4.42]）。然而，在低风险基因型的母亲中，妊娠期间SHS暴露与SGA无关（1.14 [0.64-2.04]）。
结论
CYP 2A 6 *1/*1和GSTT 1缺失基因型的中国孕妇发生SHS相关SGA的风险特别高。
INTRODUCTION
Risk of small-for-gestational-age (SGA) birth varied considerably in women exposed to secondhand smoke (SHS) during pregnancy. We examined whether this variation was explained by mothers' one Phase I (CYP2A6*4, activation of tobacco toxics) and two Phase II (GSTM1 and GSTT1, detoxification) metabolic genotypes.
METHODS
We enrolled 468 Chinese pregnant women (115 delivering SGA and 353 delivering non-SGA newborns) shortly before delivery. SHS exposure during pregnancy was defined as self-reported daily exposure time being more than 0 minute. We fitted multivariable logistic regression models to examine whether CYP2A6*4, GSTM1, and GSTT1 gene polymorphsims and their combinations modified the association between SHS exposure and SGA.
RESULTS
In the total sample, more mothers of SGA newborns were exposed to SHS during pregnancy than mothers of non-SGA newborns (38.3% vs. 31.4%). CYP2A6*4, GSTM1, and GSTT1 genes alone could not modify the association between SHS exposure and SGA. The combination of CYP2A6*4 and GSTT1 high-risk genotypes (CYP2A6*1/*1 and GSTT1-absent [high-risk] vs. other combinations as a whole [low-risk]) significantly (P value, .045) modified the association between SHS exposure and SGA. Among mothers with high-risk genotypes, SHS during pregnancy was significantly associated with SGA (confounder-adjusted odds ratio, 2.31 [95% confidence interval, 1.20-4.42]). Among mothers with low-risk genotypes, however, SHS exposure during pregnancy was not associated with SGA (1.14 [0.64-2.04]).
CONCLUSIONS
Chinese pregnant women with the combination of CYP2A6*1/*1 and GSTT1-absent genotypes are at particularly high-risk of SHS-related SGA.
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DOI：
10.1111/j.1600-0773.1986.tb00108.x
发表时间：
2009-03
期刊：
Acta pharmacologica et toxicologica
影响因子：
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作者：
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通讯作者：
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影响因子：
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DOI：
10.1136/fn.88.3.f229
发表时间：
2003-05-01
影响因子：
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