Evaluation of the dosimetric feasibility of hippocampal sparing intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma.
Evaluation of the dosimetric feasibility of hippocampal sparing intensity-modulated radiotherapy in patients with locally advanced nasopharyngeal carcinoma.
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DOI：
10.1371/journal.pone.0090007
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Wang Z
中科院分区：
文献类型：
--
作者：
Han G;Liu D;Gan H;Denniston KA;Li S;Tan W;Hu D;Zhen W;Wang Z
本研究的目的是评估局部晚期鼻咽癌（NPC）患者使用海马（HPC）保留调强放疗（IMRT）的剂量学可行性。本研究选择了 8 例 T3 或 T4 鼻咽癌病例。标准 IMRT 治疗计划是根据放射治疗肿瘤学组 (RTOG) 0615 协议，使用目标和危险器官 (OAR) 的体积和剂量限制构建的。实验计划是使用相同的标准构建的，并添加了 HPC 作为 OAR。比较每个病例的两个剂量体积直方图的目标和 OAR。所有计划均达到方案剂量标准。规划目标体积 (PTV) 的同质性指数、一致性指数和覆盖指数并未因避免 HPC 而受到显着影响。除 HPC 外，所有 OAR 的剂量相似。 HPC 备用计划中 HPC 的剂量（Dmax、D2%、D40%、Dmean、Dmedian、D98% 和 Dmin）和体积（V5、V10、V15、V20、V30、V40 和 V50）参数均显着较低 (p<0.05)，但 Dmin (P = 0.06) 和 V5 除外（P = 0.12）。对局部晚期鼻咽癌患者进行 IMRT 会使 HPC 暴露于显着的辐射剂量。节省 HPC 的 IMRT 计划显着降低了该剂量，对治疗靶点和其他 OAR 的影响最小。
The objective of this study was to evaluate the dosimetric feasibility of using hippocampus (HPC) sparing intensity-modulated radiotherapy (IMRT) in patients with locally advanced nasopharyngeal carcinoma (NPC). Eight cases of either T3 or T4 NPC were selected for this study. Standard IMRT treatment plans were constructed using the volume and dose constraints for the targets and organs at risk (OAR) per Radiation Therapy Oncology Group (RTOG) 0615 protocol. Experimental plans were constructed using the same criteria, with the addition of the HPC as an OAR. The two dose-volume histograms for each case were compared for the targets and OARs. All plans achieved the protocol dose criteria. The homogeneity index, conformity index, and coverage index for the planning target volumes (PTVs) were not significantly compromised by the avoidance of the HPC. The doses to all OARs, excluding the HPC, were similar. Both the dose (Dmax, D2%, D40%, Dmean, Dmedian, D98% and Dmin) and volume (V5, V10, V15, V20, V30, V40 and V50) parameters for the HPC were significantly lower in the HPC sparing plans (p<0.05), except for Dmin (P = 0.06) and V5 (P = 0.12). IMRT for patients with locally advanced NPC exposes the HPC to a significant radiation dose. HPC sparing IMRT planning significantly decreases this dose, with minimal impact on the therapeutic targets and other OARs.
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影响因子：
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